Marinho, Flávia Dias MarquesSantos, Amanda Leão dosSoares, Cristina Duarte ViannaReis, Ilka AfonsoZanon, José Carlos da CostaLima, Angélica Alves2014-09-292014-09-292012MARINHO, F. D. M. et al. Simvastatin assay and dissolution studies by feasible rp-hplc in tablets. Química Nova, v. 35, p. 1233-1238, 2012. Disponível em: <http://www.scielo.br/scielo.php?pid=S0100-40422012000600031&script=sci_arttext>. Acesso em: 20 ago. 2014.1678-7064http://www.repositorio.ufop.br/handle/123456789/3639Commonly used HPLC acetonitrile solvent has been through a worldwide shortage with a cost increase in 2008 and 2009. In order to get around this situation, a method by RP-HPLC employing methanol and aqueous acid mobile phase was developed and validated to evaluate simvastatin. The quality control assay and dissolution studies of this lipid-lowering drug were performed in diluents methanol and 0.01 M phosphate buffer with 0.5% SDS, pH 7, respectively. Dissolution test aliquots did not go through sample treatment, as described in USP SIM tablets monograph by ultraviolet spectrophotometry. The proposed method is fast, simple, feasible and robust.en-USSimvastatin tabletsDissolution studiesArtigo publicado em periodicoA Sociedade Brasileira de Química dá permissão à UFOP para reproduzir no RI/UFOP, uma cópia em formato eletrônico dos artigos completos, sem nenhuma edição e/ou modificação, publicados na revista Química Nova, que tenham como autores seus alunos e/ou professores. 17 set. 2013.http://dx.doi.org/10.1590/S0100-40422012000600031