Coletro, Hillary NascimentoDiniz, Amanda PopolinoGuimarães, Nathália SernizonCarraro, Júlia Cristina CardosoMendonça, Raquel de DeusMeireles, Adriana Lúcia2023-03-092023-03-092021COLETRO, H. N. et al. Polyphenols for improvement of inflammation and symptoms in rheumatic diseases: systematic review. São Paulo Medical Journal, v. 139, n. 6, p. 615-623, 2021. Disponível em: <https://www.scielo.br/j/spmj/a/9gsypp88wfZfKZrgRKqLs7D/?lang=en>. Acesso em: 11 out. 2022.1806-9460http://www.repositorio.ufop.br/jspui/handle/123456789/16329BACKGROUND: Rheumatic diseases (RDs) are a group of pathological conditions characterized by inflam- mation and functional disability. There is evidence suggesting that regular consumption of polyphenols has therapeutic effects capable of relieving RD symptoms. OBJECTIVE: To synthesize data from randomized controlled trials on administration of polyphenols and their effects on RD activity. DESIGN AND SETTING: Systematic review conducted at Universidade Federal de Ouro Preto, Minas Gerais, Brazil. METHODS: A systematic search was conducted in the databases PubMed (Medline), LILACS (BVS), IBECS (BVS), CUMED (BVS), BINACIS (BVS), EMBASE, Web of Science and Cochrane Library and in the grey litera- ture. The present study followed a PRISMA-P checklist. RESULTS: In total, 646 articles were considered potentially eligible, of which 33 were then subjected to complete reading. Out of these, 17 randomized controlled trials articles were selected to form the final sample. Among these 17 articles, 64.71% assessed osteoarthritis (n = 11), 23.53% rheumatoid arthritis (n = 4), 5.88% rheumatoid arthritis and fibromyalgia (n = 1) and 5.88% osteoarthritis and rheumatoid (n = 1). Intake of polyphenol showed positive effects in most of the studies assessed (94.12%): it improved pain (64.70%) and inflammation (58.82%). CONCLUSION: Polyphenols are potential allies for treating RD activity. However, the range of polyphenol sources administered was a limitation of this review, as also was the lack of information about the meth- odological characteristics of the studies evaluated. Thus, further primary studies are needed in order to evaluate the effects of polyphenol consumption for reducing RD activity.en-USabertoAntioxidantsRheumatic diseasesPolyphenolsRheumatoid arthritisOsteoarthritisArtigo publicado em periodicoThis is an open access article distributed under the terms of the Creative Commons license. Fonte: o PDF do artigo.https://doi.org/10.1590/1516-3180.2020.0766.R1.22042021