Amparo, Tatiane RoqueteRodrigues, Ivanildes VasconcelosSeibert, Janaína BrandãoSouza, Rafaella Hilda ZanitiOliveira, Amanda Ribeiro deCabral, Vivette Appolinário RodriguesVieira, Paula Melo de AbreuBrandão, Geraldo CélioOkuma, Adriana AkemiVieira Filho, Sidney AugustoTeixeira, Luiz Fernando de MedeirosSouza, Gustavo Henrique Bianco de2018-05-142018-05-142017AMPARO, T. R. et al. Antibacterial activity of extract and fractions from branches of Protium spruceanum and cytotoxicity on fibroblasts. Natural Product Research, v. 01, p. 1-5, 2017. Disponível em: <https://www.tandfonline.com/doi/abs/10.1080/14786419.2017.1354182?journalCode=gnpl20>. Acesso em: 05 abr. 2018.14786427http://www.repositorio.ufop.br/handle/123456789/9928The crude ethanol extract (CEE) and fractions from branches of Protium spruceanum were subjected to antibacterial and cytotoxicity assays. Compounds of the most active fraction were identified by GC-MS and LC-MS. CEE was active against 19 bacteria and the ethyl acetate fraction (EAF) showed the lowest minimum bactericidal concentration (MBC 0.3–80.0 mg/mL). Through time-kill assay was observed that EAF induced rapid bactericidal effect against Staphylococcus saprophyticus. The cytotoxicity tests against L929 fibroblasts showed great potential of EAF on the treatment of infections caused by five bacteria (MBC < IC50). The results provide in vitro scientific support to the possible application of branches of P. spruceanum as antimicrobial agent that may contribute for treatment of infections.en-USrestritoProtium spruceanumCytotoxicityAntbacterial activityArtigo publicado em periodicohttps://www.tandfonline.com/doi/abs/10.1080/14786419.2017.1354182?journalCode=gnpl20