Silva, M. C.Azevedo, Maíra AraújoFigueiredo, Vivian PaulinoMoura Junior, Manoel Ramos deCoelho Júnior, DiógenesMartinelli, Patrícia MassaraMachado, Raquel do PilarAlzamora, Andréia CarvalhoSilva, André Talvani Pedrosa da2018-10-112018-10-112018SILVA, M. C. et al. Renovascular hypertension increases serum TNF and CX3CL1 in experimental Trypanosoma cruzi infection. Brazilian Journal of Medical and Biological Research, Ribeirão Preto, v. 51, n. 5, p. e6690, 2018. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000500614&lng=en&nrm=iso&tlng=en>. Acesso em: 05 abr. 2018.1414431Xhttp://www.repositorio.ufop.br/handle/123456789/10346Trypanosoma cruzi triggers a progressive inflammatory response affecting cardiovascular functions in humans and experimental models. Angiotensin II, a key effector of the renin-angiotensin system, plays roles in mediating hypertension, heart failure, and inflammatory responses. T. cruzi and AngII can induce inflammatory responses by releasing inflammatory mediators. The aim of this study was to evaluate systemic AngII, tumor necrosis factor (TNF), and CX3CL1 mediators in a two-kidney one-clip (2K1C) renovascular hypertension model using Wistar rats infected with T. cruzi. Our data showed an increase in serum AngII in uninfected and T. cruzi-infected rats 1 week after 2K1C surgery compared to non-2K1C (Sham) animals. The baseline systolic blood pressure was higher in both uninfected and infected 2K1C rats. Despite no difference in circulating parasites in the acute phase of infection, elevated serum TNF and CX3CL1 were observed at 8 weeks post-infection in 2K1C rats in association with higher cardiac inflammatory infiltration. In summary, AngII-induced hypertension associated with T. cruzi infection may act synergistically to increase TNF and CX3CL1 in the 2K1C rat model, thereby intensifying cardiac inflammatory infiltration and worsening the underlying inflammation triggered by this protozoan.en-USabertoTumor necrosis factorCardiac inflammationRenovascular hypertension increases serum TNF and CX3CL1 in experimental Trypanosoma cruzi infection.Artigo publicado em periodicoTodo o conteúdo do periódico Brazilian Journal of Medical and Biological Research, exceto onde identificado, está licenciado sob uma licença Creative Commons 4.0 que permite copiar, distribuir e transmitir o trabalho em qualquer suporte ou formato desde que sejam citados o autor e o licenciante. Fonte: Brazilian Journal of Medical and Biological Research <http://www.scielo.br/scielo.php?script=sci_serial&pid=0100-879X&lng=en&nrm=iso>. Acesso em: 20 out. 2016.