Nascimento, Andréa Mendes doConti, RaphaelTuratti, Izabel Cristina CasanovaCavalcanti, Bruno CoêlhoLotufo, Leticia Veras CostaPessoa, CláudiaMoraes Filho, Manoel Odorico deManfrim, VivianeToledo, Juliano Simões deCruz, Angela KayselPupo, Mônica Tallarico2015-04-012015-04-012012NASCIMENTO, A. M. do et al. Bioactive extracts and chemical constituents of two endophytic strains of Fusarium oxysporum. Revista Brasileira de Farmacognosia, v. 22, p. 1276-1281, 2012. Disponível em: <http://www.scielo.br/scielo.php?pid=s0102-695x2012000600010&script=sci_arttext>. Acesso em: 02 fev. 2015.1981-528Xhttp://www.repositorio.ufop.br/handle/123456789/4862Ethyl acetate extracts of cultures grown in liquid Czapek and on solid rice media of the fungal endophyte Fusarium oxysporum SS46 isolated from the medicinal plant Smallanthus sonchifolius (Poepp.) H. Rob., Asteraceae, exhibited considerable cytotoxic activity when tested in vitro against human cancer cells. Chromatographic separation yielded anhydrofusarubin (1) and beauvericin (2) that were identified based on their 1H and 13C NMR data. Compounds 1 and 2 showed the strongest cytotoxic activity against different cancer cell lines. Compound 2 also showed promising activity against Leishmania braziliensis. Hexanic extract of F. oxysporum SS50 grown on solid rice media also afforded a mixture of compounds that displayed cytotoxic activity against different cancer cell lines. Chemical analysis of the mixture of compounds, investigated by gas chromatography-mass spectrometry (GC-MS), showed that there was a predominance of methyl esters of fatty acids and alkanes.en-USBeauvericinCitotoxic activityEndophytic fungusFusarium oxysporumLeishmania braziliensisArtigo publicado em periodicoA Revista Brasileira de Farmacognosia permite que o Repositório Institucional da Universidade Federal de Ouro Preto (UFOP) deposite uma cópia eletrônica dos artigos publicados por esse periódico  em que ao menos um dos autores faça parte da comunidade cientifica da UFOP. Fonte: Licença concedida Mediante prenchimento de formulário em 16 set. 2013.http://dx.doi.org/10.1590/S0102-695X2012005000106