Silva, Carla TeixeiraCândido, Ana Paula CarlosPala, DanielaBarbosa, Priscila OliveiraCoelho, George Luiz Lins MachadoOliveira, Fernando Luiz Pereira deVolp, Ana Carolina PinheiroFreitas, Renata Nascimento de2017-09-262017-09-262017SILVA, C. T. et al. Clustered cardiovascular risk factors are associated with inflammatory markers in adolescents. Annals of Nutrition and Metabolism, v. 70, p. 259-267, 2017. Disponível em: <https://www.karger.com/Article/FullText/458767>. Acesso em: 29 ago. 2017.1421-9697http://www.repositorio.ufop.br/handle/123456789/8799Background: Clusters of cardiovascular risk (CVR) factors are associated with an increased risk of developing cardiovascular diseases (CVDs). This cross-sectional study assessed the associations between classic CVR factor clusters and inflammatory markers in Brazilian adolescents. Methods: Measurements included anthropometric, clinical and biochemical parameters and selected inflammatory markers in 487 adolescents (236 boys/251 girls; 12.06 ± 1.41 years). Results: After stratifying the population by gender and adjusting for potential confounding variables, principal component analysis was performed and it produced 5 independent components in both genders: adiposity, glucose metabolism, blood pressure, high-density lipoprotein (HDL)/triacylglycerols (TG), and cholesterol/low-density lipoprotein. Glucose metabolism was inversely associated with interleukin-1β (IL-1β) in both genders ( r = –0.026; r = –0.021); blood pressure was inversely associated with tumor necrosis factor alpha (TNF-α) in girls ( r = –0.046); HDL/TG was positively associated with interleukin-6 in girls ( r = 0.012), with IL-1β ( r = 0.010) TNF-α ( r = 0.045) in boys, and inversely associated with adiponectin in both genders ( r = –0.015; r = –0.013). Conclusion: The results suggest that lipid metabolism alterations, as potential early events in the development of CVDs, have a strong link to the inflammatory process, in contrast to other clusters of risk factors.en-USrestritoCytokinesCardiovascular disease - risk factorsPrincipal components analysisArtigo publicado em periodicohttps://www.karger.com/Article/FullText/458767https://doi.org/10.1159/000458767