Reynaldo, Juliana RibeiroNovack, Kátia MonteiroSousa, Lucas Resende DutraVieira, Paula Melo de AbreuAmparo, Tatiane RoqueteSouza, Gustavo Henrique Bianco deTeixeira, Luiz Fernando de MedeirosBarboza, Ana Paula MoreiraNeves, Bernardo Ruegger AlmeidaAlvarenga, Meiry EdivirgesMartins, Felipe TerraSantos, Viviane Martins Rebello dos2023-08-172023-08-172022REYNALDO, J. R. et al. Evaluation of anti-candida albicans activity and release of ketoconazole in PMMA-G-PEG 4000 films. International Journal of Molecular Sciences, v. 23, n. 18, artigo 10775, 2022. Disponível em: <https://www.mdpi.com/1422-0067/23/18/10775>. Acesso em: 06 jul. 2023.1422-0067http://www.repositorio.ufop.br/jspui/handle/123456789/17230Modified release systems depend on the selection of an appropriate agent capable of controlling the release of the drug, sustaining the therapeutic action over time, and/or releasing the drug at the level of a particular tissue or target organ. Polyethylene glycol 4000 (PEG 4000) is commonly employed in drug release formulations while polymethyl methacrylate (PMMA) is non-toxic and has a good solubility in organic solvents. This study aimed at the incorporation of ketoconazole in PMMA-g-PEG 4000 and its derivatives, thus evaluating its release profile and anti-Candida albicans and cytotoxic activities. Ketoconazole was characterized and incorporated into the copolymers. The ketoconazole incorporated in the copolymer and its derivatives showed an immediate release profile. All copolymers with ketoconazole showed activity against Candida albicans and were non-toxic to human cells in the entire concentration tested.en-USabertoArtigo publicado em periodicoThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). Fonte: PDF do artigo.https://doi.org/10.3390/ijms231810775