Araujo Neto, João Honorato deOliveira, Katia Mara deLeite, Celisnolia M.Colina Vegas, Legna AndreinaNóbrega, Joaquim de AraújoCastellano, Eduardo ErnestoEllena, Javier AlcidesCorrea, Rodrigo de SouzaBatista, Alzir Azevedo2021-12-162021-12-162020ARAÚJO NETO, J. H. de et al. "Half-sandwich"/RuII anticancer complexes containing triphenylphosphine and p-substituted benzoic acids. Journal of the Brazilian Chemical Society, v. 31, p. 2237-2249, 2020. Disponível em: <https://www.scielo.br/j/jbchs/a/qtVP9v3z5JxyJHY6HYKXW4s/abstract/?lang=en>. Acesso em: 10 jun. 2021.1678-4790http://www.repositorio.ufop.br/jspui/handle/123456789/14247Mononuclear and binuclear RuII/arene/triphenylphosphine complexes with p-substituted benzoic acid derivatives were prepared and characterized. These monocationic complexes of type [Ru(η6 -p-cymene)(PPh3)L] (L = benzoic acid (1), p-hydroxybenzoic acid (2), p-nitrobenzoic acid (3) and terephthalic acid (4)) were characterized using various techniques, such as nuclear magnetic resonance (NMR) and matrix-assisted laser desorption/ionization-time of flight (MALDI-TOF) mass spectrometry, and the crystal structure of 1, 3 and 4 were determined by X-ray diffraction analysis. The cytotoxicity of the complexes was evaluated, in vitro, against tumorigenic [MDA-MB-231, MCF-7 (breast), A549 (lung) and DU-145 (prostate)] and non-tumorigenic [MCF-10A (breast), MRC-5 (lung) and PNT-2 (prostate)] cells. The binuclear complex (4) was inactive due to its low solubility. Complexes 1, 2 and 3 showed similar cytotoxicity, however, complex 1 presented better selectivity index against MDA-MB-231 than compounds 2 and 3. Cellular ruthenium absorption was explored by inductively coupled plasma mass spectrometry (ICP-MS) analyzing the whole cells and the culture medium. Complementary studies showed that complex 1 inhibited colony formation, induced morphology changes in cells and promoted cell cycle arrest in the Sub-G1 phase for the MDA-MB-231 cells.en-USabertoPiano-stool RuII complexesBenzoic acid analogsCellular uptakeArtigo publicado em periodicoThis is an open-access article distributed under the terms of the Creative Commons Attribution License. Fonte: o PDF do artigo.https://doi.org/10.21577/0103-5053.20200076