Lopes, Ana Cristina dos SantosPerucci, Luiza OliveiraEvangelista, Fernanda Cristina GontijoGodoi, Lara CarvalhoSabino, Adriano de PaulaGomes, Karina BragaSilva, André Talvani Pedrosa daDusse, Luci Maria Sant AnaAlpoim, Patrícia Nessralla2020-03-102020-03-102019LOPES, A. C. S. et al. Association among ACE, ESR1 polymorphisms and preeclampsia in Brazilian pregnant women. Molecular and cellular probes, v. 45, p. 43-47, jun. 2019. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0890850819300350?via%3Dihub>. Acesso em: 10 fev. 2020.0890-8508http://www.repositorio.ufop.br/handle/123456789/11972Background: Genetic, immune and environmental factors are involved in preeclampsia (PE) etiopathogenesis. Considering that hypertension and poor placental perfusion are important features in PE, polymorphisms in the angiotensin-converting enzyme (ACE) and estrogen nuclear receptor 1 (ESR1) genes could be involved in the predisposition and/or development of the disease. The aim of this study was to evaluate if polymorphisms in ACE and ESR1 genes were associated with PE occurrence. Material and Methods: This case-control study included 209 Brazilian pregnant women (107 with severe PE and 102 normotensive controls). The polymorphisms were investigated by polymerase chain reaction (PCR) followed by polyacrylamide gel electrophoresis. Results: No significant difference between PE versus normotensive pregnant women, as well as early versus late PE, was observed when compared the allelic and genotypic frequencies of insertion/deletion polymorphism in intron 16 of the ACE gene and the single nucleotide polymorphisms (SNPs - rs2234693 and rs9340799) of the ESR1 gene. Conclusion: This pioneer study involving Brazilian women showed no association among the studied polymorphisms and PE, which suggests that ins/del ACE and SNPs ESR1 do not contribute to this disease occurrence in Brazil.en-USrestritoPreeclampsiaHypertensionArtigo publicado em periodicohttps://www.sciencedirect.com/science/article/pii/S0890850819300350?via%3Dihubhttps://doi.org/10.1016/j.mcp.2019.04.004