Lucas Filho, Milton DayrellSilva, Grazielle Caroline daCôrtes, Steyner de FrançaGuia, Thiago Rennó dos MaresFerraz, Vany PerpetuaSerra, Carla PenidoBraga, Fernão Castro2012-07-302012-07-302010LUCAS FILHO, M. D. et al. ACE inhibition by astilbin isolated from Erythroxylum gonocladum (Mart.) O.E. Schulz. Phytomedicine, v. 17, n. 5, p. 383-387, abr. 2010. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0944711309002372>. Acesso em: 30 jul. 2012.09447113http://www.repositorio.ufop.br/handle/123456789/1214Erythroxylum species have several traditional uses in different countries, including the treatment of hypertension. The ethanol extract from E. gonocladum aerial parts, a species endemic to the Brazilian cerrado, elicited a concentration-dependent inhibition of angiotensin converting enzyme (ACE) (pIC50=4.53±0.05). Extract fractionation led to the isolation of two compounds, whose structures were assigned by spectrometric data as astilbin and β-sitosterol, along with a mixture of palmitic, stearic and linolenic acids. This is the first report on the occurrence of these compounds on E. gonocladum. Astilbin promoted significant ACE inhibition in vitro (pIC50=5.86±0.33) and its activity did not differ from captopril, when both compounds were assayed at 10 μM concentration.en-USAstilbinErythroxylum gonocladumIn vitro angiotensin converting enzyme inhibitory activityArtigo publicado em periodicoO periódico Phytomedicine concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3347180657438.