Silva, Marcelo EustáquioSilva, Marcílio Eustáquio de CastroNicoli, Jacques RobertBambirra, Eduardo AlvesVieira, Enio Carlos2015-03-252015-03-251993SILVA, M. E. et al. Vitamin D overload and experimental Trypanosoma cruzi infection: parasitological and histopathological aspects. Comparative Biochemistry and Physiology, Londres, v. 104, n.1, p. 175-181, 1993. Disponível em: <http://www.sciencedirect.com/science/article/pii/030096299390026Z>. Acesso em: 20 fev. 2015.1095-6433http://www.repositorio.ufop.br/handle/123456789/4742l. Six groups of 45-day-old, 23.0 & 1.7 g, female Balb/c mice were inoculated intraperitoneally with 63, 252, 440, 630, 2520 or 6300 I.U. of vitamin D for 6 days. A seventh group was inoculated with saline. Each group consisted of 30 animals. 2. All animals inoculated with the doses of 2520 and 6300 and 70% of mice which received 630 I.U. of vitamin D died 21 days after the first administration of the vitamin. The LDm was 630 I.U. 3. The survivors were divided into two groups inoculated intraperitoneally with 5000 trypomastigotes of either Y or CL strain of Trypanosoma cruzi. 4. Based on the survival index on day 73 after infection, Vitamin D gave statistically significant protection (P < 0.01) for mice inoculated with doses of 63 or 430 I.U. of Y or CL strains, respectively. 5. On histopathological examination, inflammatory reaction and cellular and tissue parasitism were less intense in animals which received higher doses of vitamin D. 6. It is concluded that an overload of vitamin D had a protective effect against CL and Y strains of Trypanosoma cruzi infection in Balb/c mice.en-USVitamin DArtigo publicado em periodicoO periódico Comparative Biochemistry and Physiology Part A: Physiology concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3577160156339.https://doi.org/10.1016/0300-9629(93)90026-Z