Arantes, Jerusa MarildaPedrosa, Maria LúciaMartins, Helen RodriguesVeloso, Vanja MariaLana, Marta deBahia, Maria TerezinhaTafuri, Washington LuizCarneiro, Cláudia Martins2012-09-192012-09-192007ARANTES, J. M. et al. Trypanosoma cruzi : treatment with the iron chelator desferrioxamine reduces parasitemia and mortality in experimentally infected mice. Experimental Parasitology, v. 117, n. 1, p. 43–50, set. 2007. Disponível em: <https://www.sciencedirect.com/science/article/pii/S001448940700080X>. Acesso em: 19 set. 2012.00144894http://www.repositorio.ufop.br/handle/123456789/1406The effects of prolonged treatment with iron chelator (desferrioxamine) on the development of infection in mice inoculated with Y Trypanosoma cruzi were determined. Infected/treated mice presented lower levels of parasitemia and reduced mortality rate compared with infected/non-treated animals. The five out of twenty infected/treated mice that survived the acute phase of infection showed negative hemoculture and positive ELISA in the acute and chronic phases and positive PCR in the acute phase: in the chronic phase, three of the animals presented negative PCR. The single surviving infected/non-treated animal exhibited positive hemoculture, PCR and ELISA in both phases of infection. Infected groups presented lower levels of iron in the liver compared with treated/non-infected or non-treated/ non-infected animals. The serum iron levels of the infected/non-treated group were higher on the 21st day post-infection in comparison with control and infected/treated groups. These results suggest that decrease of iron in the host leads to T. cruzi infection attenuation.en-USArtigo publicado em periodicoO periódico Experimental Parasitology concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3281990280591.