Antunes, Amanda dos SantosGouveia, Ana Paula AraújoDiogo, Gabriela MacielTaylor, Jason GuySousa, Lucas Resende DutraAmparo, Tatiane RoquetePerasoli, Fernanda BarçanteSantos, Orlando David Henrique dosCazati, ThiagoVieira, Paula Melo de AbreuPenido, Ricardo GonçalvesSantos, Viviane Martins Rebello dos2021-12-212021-12-212021ANTUNES, A. dos S. et al. In vitro photoprotective evaluation and development of novel nanoemulsion with chromone derivative. Journal of the Brazilian Chemical Society, v. 32, n. 9, p. 1813-1821, 2021. Disponível em: <http://static.sites.sbq.org.br/jbcs.sbq.org.br/pdf/2021-0089AR.pdf>. Acesso em: 10 jun. 2021.1678-4790http://www.repositorio.ufop.br/jspui/handle/123456789/14284Chromone derivatives exhibiting high absorbance values in the UVA/UVB region were synthesized, and their photoprotective properties were evaluated. Chromones were prepared according to known literature procedures and characterized by high resolution mass spectrometry, infrared (IR) and nuclear magnetic resonance (NMR) spectroscopy. The in vitro solar protection factor (SPF) was determined by the Mansur method and cytotoxicity was evaluated using the sulforhodamine B assay. Two of the chromones synthesized demonstrated suitable SPF values and displayed no cytotoxic effect towards MRC-5 human fibroblasts at the tested concentrations, indicating great potential for future in vivo assays and clinical trials. Finally, the lead compound was incorporated into a nanoemulsion. Nanoemulsions showed high droplet size homogeneity and excellent stability. Chromones bearing methoxy substituents were found to be the most promising compounds with ideal photoprotective properties desirable for utilization and incorporation in sunscreen formulations.en-USabertoMansurOrganic UV filtersCytotoxicityArtigo publicado em periodicoThis is an open-access article distributed under the terms of the Creative Commons Attribution License. Fonte: o PDF do artigo.https://dx.doi.org/10.21577/0103-5053.20210072