Amancio, Gabriela de Cássia SousaHermidorff, Milla MarquesAlvarenga, Ana CláudiaLima, Wanderson Geraldo deGuimarães, Homero NogueiraRodrigues, Henrique ResendeSilva, Emília CalilAssis, Leonardo Vinícius Monteiro deGuimarães, Andrea GrabeIsoldi, Mauro César2022-11-042022-11-042022AMANCIO, G. de C. S. et al. Spironolactone and eplerenone are cardioprotective during early phase of ischemia in rats submitted to acute coronary occlusion. Research, Society and Development, v. 11, n. 3, 2022. Disponível em: <https://rsdjournal.org/index.php/rsd/article/view/26498>. Acesso em: 11 out. 2022.2525-3409http://www.repositorio.ufop.br/jspui/handle/123456789/15736Introduction: Mineralocorticoid receptor antagonists (MRAs) are effective in reducing left ventricle remodeling and sudden death after acute myocardial infarction (AMI). Objectives: MRAs in vitro display cardioprotective effects, independent of MR; however, it is unknown whether the rapid effects of MRAs are cardioprotective in vivo. This study evaluated the acute effects of spironolactone and eplerenone in the first minutes of AMI. Methods: Wistar Rats, submitted or not to bilateral adrenalectomy, were treated orally with spironolactone (20 mg/kg) or eplerenone (10 mg/kg), and submitted to the left coronary ligation, under anesthesia. Electrocardiogram (ECG) recordings were obtained to evaluate ST-T segment, QT, and QTc intervals. Arterial pressure was also measured before (baseline) and after coronary ligation. Results: Spironolactone or eplerenone given, one hour before coronary ligation, prevented ST- T segment elevation in adrenalectomized and non-adrenalectomized. QT interval analysis showed that MRAs prevented its prolongation after coronary ligation. QT and QTc intervals remained similar to baseline and were smaller than the values displayed by the non-treated group. Animals treated with spironolactone, regardless of adrenalectomy, showed a 3-fold reduced mortality rates compared to the control group. Conclusion: MRAs display acute cardioprotective effects in early phase of AMI, which are independent of aldosterone.en-USabertoAcute myocardial infarctionElectrocardiogramInfarto agudo do miocárdioEletrocardiogramaArtigo publicado em periodicoThis is an open-access article distributed under the terms of the Creative Commons Attribution License. Fonte: o PDF do artigo.http://dx.doi.org/10.33448/rsd-v11i3.26498