Maksud, Fabiana Alves NunesKakehasi, Adriana MariaGuimarães, M. F. B. R.Machado, Carla JorgeBarbosa, Alfredo José Afonso2017-09-222017-09-222017MAKSUD, F. A. N. et al. Ghrelin plasma levels, gastric ghrelin cell density and bone mineral density in women with rheumatoid arthritis. Brazilian Journal Of Medical And Biological Research, v. 50, p. 1-6, 2017. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000600704&lng=en&nrm=iso&tlng=en>. Acesso em: 29 ago. 2017.1414-431Xhttp://www.repositorio.ufop.br/handle/123456789/8773Generalized bone loss can be considered an extra-articular manifestation of rheumatoid arthritis (RA) that may lead to the occurrence of fractures, resulting in decreased quality of life and increased healthcare costs. The peptide ghrelin has demonstrated to positively affect osteoblasts in vitro and has anti-inflammatory actions, but the studies that correlate ghrelin plasma levels and RA have contradictory results. We aimed to evaluate the correlation between total ghrelin plasma levels, density of ghrelin-immunoreactive cells in the gastric mucosa, and bone mineral density (BMD) in twenty adult women with established RA with 6 months or more of symptoms (mean age of 52.70±11.40 years). Patients with RA presented higher ghrelin-immunoreactive cells density in gastric mucosa (P=0.008) compared with healthy females. There was a positive relationship between femoral neck BMD and gastric ghrelin cell density (P=0.007). However, these same patients presented a negative correlation between plasma ghrelin levels and total femoral BMD (P=0.03). The present results indicate that ghrelin may be involved in bone metabolism of patients with RA. However, the higher density of ghrelin-producing cells in the gastric mucosa of these patients does not seem to induce a corresponding elevation in the plasma levels of this peptide.en-USabertoGastric mucosaBone metabolismOsteoporosisRheumatoid arthritisArtigo publicado em periodicoOs trabalhos publicados no periódico Brazilian Journal of Medical and Biological Research, exceto onde identificado, estão sob uma licença Creative Commons que permite copiar, distribuir e transmitir o trabalho desde que sejam citados o autor e o licenciante. Fonte: Brazilian Journal of Medical and Biological Research <http://www.scielo.br/scielo.php?script=sci_serial&pid=0100-879X&lng=en&nrm=iso>. Acesso em: 31 jan. 2020.http://dx.doi.org/10.1590/1414-431x20175977