Browsing by Author "Hermsdorff, Helen Hermana Miranda"

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    Artrite reumatoide experimental : o papel do consumo da polpa de açaí (Euterpe oleracea Mart.) no estresse oxidativo e na inflamação.
    (2019) Silva, Carla Teixeira; Freitas, Renata Nascimento de; Amaral, Joana Ferreira do; Freitas, Renata Nascimento de; Magalhães, Cíntia Lopes de Brito; Hermsdorff, Helen Hermana Miranda; Peluzio, Maria do Carmo Golveia; Pedrosa, Maria Lúcia
    A artrite reumatoide (AR) é uma doença autoimune caracterizada por inflamação sinovial crônica que conduz a uma destruição articular/óssea e associa-se à incapacitação progressiva, complicações sistêmicas, morbidade e mortalidade precoce. O processo de destruição da articulação observado na artrite reumatoide é mediado por vias intracelulares de sinalização, que envolvem fatores de transcrição, tais como o fator nuclear κB, citocinas, quimiocinas, fatores de crescimento, ligantes celulares, e moléculas de adesão. A produção excessiva de espécies reativas de oxigênio (ERO) pode levar ao aumento da inflamação na AR em humanos e animais. O consumo de alimentos com putativos efeitos funcionais em humanos e modelos experimentais de AR tem mostrado efeitos benéficos no controle dos sintomas O açaí (Euterpe oleracea Mart.), fruto rico em polifenóis, insere-se neste contexto pois apresenta alta capacidade antioxidante e propriedades anti-inflamatórias. Assim, o objetivo deste estudo foi verificar o efeito do consumo da polpa de açaí sobre marcadores do metabolismo oxidativo e inflamatórios de camundongos C57BL/6 portadores de artrite induzida por antígeno (mBSA). Camundongos C57BL/6 fêmeas foram divididos em cinco grupos experimentais: três grupos (C, AR e AÇT) receberam dieta padrão AIN-93M e outros dois (AÇ e AÇP) receberam uma dieta com 2% de açaí, ao longo de 2 semanas. Após este período, foi realizada uma imunização na base da cauda dos animais dos grupos AR, AÇP e AÇT, com emulsão composta por mBSA+CFA+Mycobactrium tuberculosis. Neste momento, o grupo AÇT passou a receber dieta com 2% de açaí. Novamente, após duas semanas, os mesmos animais receberam um desafio intra-articular contendo mBSA. Os animais foram eutanasiados após 24h desse desafio. Camundongos do grupo AR apresentaram aumento na produção de anticorpos anti-mBSA, maior edema de pata e infiltrado inflamatório articular, maior peso de órgãos linfoides, aumento do estresse oxidativo e da produção de citocinas pró- inflamatórias. O consumo de açaí na dieta mostrou efeito protetor sobre a AR, com redução na produção de anticorpos, do edema e infiltrado inflamatório, como consequência da melhora no balanço oxidante/antioxidante local e modulação na produção de citocinas e balanço de células Treg/Th17 de forma sistêmica. Estes resultados mostram a necessidade da realização de mais estudos que melhor esclareçam os mecanismos aqui envolvidos, e apontam para um possível efeito antioxidante e anti-inflamatório do açaí na AR experimental, possibilitando sua utilização como estratégia dietética preventiva e/ou terapêutica para a doença.
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    Baseline diet quality is related to changes in the body composition and inflammatory markers : an intervention study based on resistance training and nutritional advice.
    (2021) Coelho, Daniel Barbosa; Lopes, Lilian Maria Peixoto; Oliveira, Emerson Cruz de; Becker, Lenice Kappes; Costa, Guilherme de Paula; Hermsdorff, Helen Hermana Miranda; Silva, Fernanda Guimarães Drummond e; Pinto, Kelerson Mauro de Castro; Silva, André Talvani Pedrosa da; Carraro, Júlia Cristina Cardoso
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    Built and social environments and overweight among Brazilian adults from medium-sized city : CUME Project.
    (2022) Domingos, Ana Luiza Gomes; Hermsdorff, Helen Hermana Miranda; Mendes, Larissa Loures; Oliveira, Fernando Luiz Pereira de; Oliveira, Anderson Castro Soares de; Pimenta, Adriano Marçal; Bressan, Josefina
    A cross-sectional study enrolled participants from the CUME project (n = 289) who lived in Viçosa, Brazil. The neighborhood unit adopted was the buffer (200 meters), considering the participant’s residence as central point. We measure the number of public and private facilities inside the buffer as well as violent criminal occurrences. Food establishments were categorized into establishments with predominant sale of natural or minimally processed foods, mixed establishments, and establishments with predominant sale of ultra-processed foods. Those who attended the face-to-face interview filled two scales of perception of the environment. Overall, 33.6% of participants reported overweight. We observed a higher concentration of individuals close to the central region of the city. Access to different establishments, food environments, and criminal occurrences differed between normal-weight and overweight individuals. The groups deferred in the perception of the location of squares, open public spaces, clubs, and soccer fields. The results indicate the association between environmental characteristics and overweight in Brazilian adults.
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    Cohort profile : the cohort of universities of Minas Gerais (CUME).
    (2018) Domingos, Ana Luiza Gomes; Miranda, Aline Elizabeth da Silva; Pimenta, Adriano Marçal; Hermsdorff, Helen Hermana Miranda; Oliveira, Fernando Luiz Pereira de; Santos, Luana Caroline dos; Lopes, Aline Cristine Souza; Martínez González, Miguel Ángel; Bressan, Josefina
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    Contribution of gender and body fat distribution to inflammatory marker concentrations in apparently healthy young adults.
    (2012) Hermsdorff, Helen Hermana Miranda; Volp, Ana Carolina Pinheiro; Puchau, Blanca; Barbosa, Kiriaque Barra Ferreira; Zulet, Maria Angeles; Bressan, Josefina; Martínez, José Alfredo
    This cross-sectional study assessed the potential contribution of gender, body fat distribution, and their interactions to some inflammatory marker concentrations [C-reactive protein (CRP), complement factor 3 (C3), and ceruloplasmin (Cp)] in young adults.
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    Dietary folate intake is negatively associated with excess body weight in brazilian graduates and postgraduates (CUME project).
    (2019) Pereira, Gabriela Amorim; Bressan, Josefina; Oliveira, Fernando Luiz Pereira de; Sant'Ana, Helena Maria Pinheiro; Pimenta, Adriano Marçal; Lopes, Liliane Teixeira; Hermsdorff, Helen Hermana Miranda
    Folate, vitamin B6, and vitamin B12 intake can be important regulators for obesity development. Thus, we investigated the possible association between the intake of these vitamins and the excess body weight or obesity prevalence in the participants of the Cohort of Universities in Minas Gerais (CUME project). This study analyzed cross-sectional data of 2695 graduates and postgraduates from universities in the state of Minas Gerais (801 men, 1894 women, ages 36.2 ± 9.4). The first step consisted of collecting data online, and the second step consisted of blood collecting in the subsample living in the city of Viçosa and its region (Minas Gerais). Excess body weight and obesity prevalence were 38.1% and 10.1%, respectively. Inadequate intake of folate, B6, and B12 were 12, 6.3, and 11.1%, respectively. Beans/lentils and French bread presented the highest contribution to folate intake (23.45% and 10.01%, respectively). Those individuals in the third tertile for folate intake (≥511.12 µg/d) had a lower excess body weight [prevalence ratio (PR): 0.79, confidence interval (CI): 0.71–0.8] and obesity prevalence (PR: 0.60, CI: 0.45–0.78). These associations were maintained when the sample was categorized by sex. In addition, serum folate was positively associated with dietary folate (p for trend = 0.032) and negatively associated with serum homocysteine (p for trend = 0.003) in the subsample. Dietary folate intake was negatively associated with excess body weight and obesity in CUME participants, indicating the relevance of this vitamin dietary assessment.
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    Dietary total antioxidant capacity is inversely related to central adiposity as well as to metabolic and oxidative stress markers in healthy young adults.
    (2011) Hermsdorff, Helen Hermana Miranda; Puchau, Blanca; Volp, Ana Carolina Pinheiro; Barbosa, Kiriaque Barra Ferreira; Bressan, Josefina; Zulet, Maria Angeles; Martínez, José Alfredo
    Background: Dietary total antioxidant capacity (TAC) has been assumed as a useful tool to assess the relationship between the cumulative antioxidant food capacity and several chronic disorders. The aim of this cross-sectional study was to investigate the potential relationships of dietary TAC with adiposity, metabolic and oxidative stress markers in healthy young adults. Methods: This study enrolled 266 healthy subjects (105 men/ 161 women; 22 ± 3 years-old; 22.0 ± 2.7 kg/m2). Dietary intake, anthropometry, blood pressure, lifestyle features, and biochemical data were assessed with validated procedures. Results: In linear regression analyses, dietary TAC values were inversely associated with glycemia, total cholesterol: HDL-c ratio, triglycerides and oxidized-LDL concentrations, and positively associated with HDL-c concentrations, independently of gender, age, smoking status, physical activity, vitamin use supplement, waist circumference, energy intake, fatty acid intake. In addition, plasma TAC was negatively correlated with ox-LDL concentrations (r= -0.20, P = 0.003), independently of the assessed confounding variables. Finally, dietary TAC values were inversely related to waist circumference values (r= -0.17, P = 0.005) as well as to lower mild central obesity occurrence (waist circumference ≥ 80/ 94 cm for women/ men, respectively). Conclusion: Dietary TAC values are inversely associated with glucose and lipid biomarkers as well as with central adiposity measurements in healthy young adults, indicating dietary TAC as a useful tool to assess the health benefits of cumulative antioxidant capacity from food intake. In addition, the independent and inverse relationships of ox-LDL concentrations with dietary and plasma TAC respectively suggest a putative role of antioxidant rich-diet in the link between redox state and atherogenesis at early stage.
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    Efeitos antioxidantes do selênio e seu elo com a inflamação e síndrome metabólica.
    (2010) Volp, Ana Carolina Pinheiro; Bressan, Josefina; Hermsdorff, Helen Hermana Miranda; Zulet, Maria Angeles; Martínez, José Alfredo
    O estado inflamatório crônico e de baixo grau bem como o estresse oxidativo associados à síndrome metabólica são fatores de risco relevantes para o desenvolvimento de doenças cardiovasculares. Neste contexto, o selênio é um mineral essencial que se encontra associado com o correto funcionamento dos principais processos metabólicos celulares. Estudos in vitro e in vivo em modelos experimentais de síndrome metabólica, bem como em humanos, tem investigado o efeito do selênio sobre a expressão e secreção de biomarcadores de inflamação e de estresse oxidativo. Para obtenção dos artigos sobre efeitos antioxidantes do selênio foram feitas pesquisas nos websites científicos. Na literatura encontramos numerosos artigos sobre os diferentes parâmetros modulados pelas concentrações plasmáticas de selênio, incluindo a proteína-C reativa, a interleucina-6, o fator de necrose tumoral-, a interleucina-1e a proteína transportadora de retinol-4. Esta revisão teve por objetivo discutir o papel do selênio nos processos inflamatórios e de estresse oxidativo, associados à síndrome metabólica.
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    Effects of minimally and ultra-processed foods on blood pressure in Brazilian adults : a two-year follow up of the CUME project.
    (2023) Alves, Katiusse Rezende; Hermsdorff, Helen Hermana Miranda; Miranda, Aline Elizabeth da Silva; Bressan, Josefina; Mendonça, Raquel de Deus; Oliveira, Fernando Luiz Pereira de; Pimenta, Adriano Marçal
    Aim: To assess the association of food consumption according to degree of processing with changes in systolic (SBP) and diastolic (DBP) blood pressure in adult participants of a Brazilian cohort. Methods: Longitudinal study with 2496 adult participants of the Cohort of Universities of Minas Gerais (CUME Project). Food consumption was categorized by food groups according to degree of processing following the NOVA grading system: unprocessed/minimally processed foods/culinary ingredients (U/MPF&CI), processed foods (PFs) and ultra-processed foods (UPFs). unprocessed/ minimally processed foods/culinary ingredients (U/MPF&CI), processed foods (PFs) and ultra-processed foods (UPFs). Changes in SBP and DBP were categorized (decreased, maintained, increased). Independent associations between exposure and outcomes were verified using multiple generalized ordered logistic models adjusted for potential confounders. Results: After a two-year follow-up, the consumption of U/MPF&CI (% daily caloric intake) reduced the chance of increasing DBP (P for trend ¼ 0.014), with a more evident effect among participants within the 5th quintile of this food group (odds ratio (OR) ¼ 0.55; 95% confidence interval (CI): 0.34–0.97]. On the other hand, the consumption of UPFs (% daily caloric intake) raised the chance of increasing DBP (P for trend ¼ 0.005) and was more evident among participants within the quintiles of higher consumption (4th quintile – OR ¼ 1.97; 95% CI: 1.25–3.10; 5th quintile – OR ¼ 1.79; 95% CI ¼ 1.12– 2.86). No associations were found between food consumption according to degree of processing and changes in SBP. Conclusion: Higher consumption of U/MPF&CI and UPFs were independently associated to lower and greater chances of increased DBP in adult participants from CUME Project.
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    Gender-specific relationships between plasma oxidized low-density lipoprotein cholesterol, total antioxidant capacity, and central adiposity indicators.
    (2014) Hermsdorff, Helen Hermana Miranda; Barbosa, Kiriaque Barra Ferreira; Volp, Ana Carolina Pinheiro; Puchau, Blanca; Bressan, Josefina; Zulet, Maria Angeles; Martínez, José Alfredo
    Oxidative stress has a pivotal role in the onset of obesity-related chronic diseases. This study assessed potential gender differences in the associations of adiposity (total vs. central) with oxidative stress markers in healthy young adults.
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    Higher fruit intake is related to TNF-α hypomethylation and better glucose tolerance in healthy subjects.
    (2016) Carraro, Júlia Cristina Cardoso; Hermsdorff, Helen Hermana Miranda; Mansego, Maria Luisa; Zulet, Maria Angeles; Milagro, Fermín Ignacio; Bressan, Josefina; Martínez, J. Alfredo
    Background/Aim: This study hypothesized an association between healthy dietary patterns, hypermethylation of the tumor necrosis factor-α (TNF-α) promoter and decreased risk of metabolic changes. Methods: Forty normal-weight young women were involved in this crosssectional study. DNA was isolated from white blood cells, and CpG site methylation in TNF-α was analyzed by Sequenom EpiTyper. The quality of the diet was assessed by Healthy Eating Index (HEI-2005). Results: Contradicting our hypothesis, HEI-2005 score was negatively associated with CpG5 (r = –0.460, p = 0.003) and TNF-α total methylation (r = –0.355, p = 0.026). A higher intake of fruits was related to lower insulin, HOMA-IR, and TNF-α methylation. No other dietary pattern was related to TNF-α methylation. TNF-α total methylation correlated positively with systolic blood pressure (r = 0.323; p = 0.042) and CpG5 methylation with body mass index (r = 0.333, p = 0.036). Furthermore, fiber intake was negatively associated with the CpG5 (r = –0.324, p = 0.041) and TNF-α total methylation (r = –0.434, p = 0.005), whereas vitamin C intake was negatively associated with TNF-α total methylation (r = –0.411, p = 0.009). Intakes of apples and citrus fruits were negatively associated with TNF-α total methylation. Conclusion: A healthy dietary pattern and higher fruit intake (particularly apples and citrus fruits) were related to better glucose tolerance in healthy subjects, which could be mediated by lower TNF-α methylation.
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    Influence of dietary total antioxidant capacity on the association between smoking and hypertension in Brazilian graduates.
    (2021) Sabião, Thaís da Silva; Bressan, Josefina; Pimenta, Adriano Marçal; Hermsdorff, Helen Hermana Miranda; Oliveira, Fernando Luiz Pereira de; Mendonça, Raquel de Deus; Carraro, Júlia Cristina Cardoso; Aguiar, Aline Silva de
    Background and aims: Hypertension (HTN) is a chronic non-communicable disease influenced by non-modifiable risk factors, such as sex and age, as well as modifiable risk factors such as lifestyle, including diet and smoking. Moreover, diet quality among smokers is worse than that of non-smokers, mainly in terms of antioxidant content. Thus, the current study aimed to investigate whether dietary total antioxidant capacity (dTAC) influences the association be- tween smoking and HTN. Methods and results: This cross-sectional study included 4303 graduates (69.35% women) from the Cohort of Minas Gerais Universities (CUME) project. An online food frequency questionnaire was administered to participants, and dTAC was estimated using the ferric reducing antioxidant power method. In the questionnaires, individuals reported smoking status, systolic and diastolic blood pressure values, previous HTN diagnosis, and use of antihypertensive drugs. Logistic regression models were used to estimate the odds ratio and 95% confidence interval between smoking and HTN, stratified by the median dTAC. Current and former smokers had higher dTAC values despite their lower fruit intake. Moreover, coffee was the main contributor to dTAC among them. Smoking was associated with a higher likelihood of HTN, mainly among individuals with a higher dTAC. However, after exclusion of coffee antioxidant capacity, there was an association be- tween only smoking and HTN in individuals with lower dTAC. Conclusions: The controversial association between higher dTAC and HTN can result from high coffee intake. Higher dTAC without coffee intake may mitigate the association between smoking and HTN in this population.
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    Interleukin-6 is a better metabolic biomarker than interleukin-18 in young healthy adults.
    (2015) Carraro, Júlia Cristina Cardoso; Hermsdorff, Helen Hermana Miranda; Puchau, Blanca; Zulet, Maria Angeles; Milagro, Fermín Ignacio; Martínez, J. Alfredo
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    MTHFR and MTR polymorphisms and breast cancer in Brazilian women.
    (2016) Conceição, Lisiane Lopes da; Pessoa, Milene Cristine; Hermsdorff, Helen Hermana Miranda; Freitas, Renata Nascimento de; Peluzio, Maria do Carmo Gouveia
    Breast cancer (BC) is the second most common cancer, and mortality rates remain high among Brazilian women. However, the role of single nucleotide polymorphisms (SNPs) in one-carbon metabolism genes in breast cancer in Brazilian women is less clear. We aimed examine the association between the SNPs, in two genes in one-carbon metabolism alone and in cumulation, and the risk of breast cancer in an Brazilian population based case-control study of 257 breast cancer cases and 177 controls. Our hypothesis was woman who carries more risk genotypes has a higher susceptibility for developing breast cancer. Genotyping for MTHFR C677T and MTR A2756G polymorphisms were performed using polymerase chain reaction-restriction fragment length polymorphism analysis (PCR-RFLP) method. Our results in population studied indicated that 677 C>T and 2756 A>G substitution does not appear to influence the risk of breast cancer. The cumulative effect was not observed with the OR being gradually elevated with increasing number of risk genotypes. However, larger studies are needed to further examine this interactions in this pathway and breast cancer risk in Brazilian women, as well in women of others nationalities.
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    Relation between uric acid and metabolic syndrome in subjects with cardiometabolic risk.
    (2015) Silva, Hellen Abreu da; Carraro, Júlia Cristina Cardoso; Bressan, Josefina; Hermsdorff, Helen Hermana Miranda
    Objective: To identify possible relations between serum uric acid levels and metabolic syndrome and its components in a population with cardiometabolic risk. Methods: This cross-sectional study included 80 subjects (46 women), with mean age of 48±16 years, seen at the Cardiovascular Health Program. Results: The prevalence of hyperuricemia and metabolic syndrome was 6.3% and 47.1%, respectively. Uric acid level was significantly higher in individuals with metabolic syndrome (5.1±1.6mg/dL), as compared to those with no syndrome or with pre-syndrome (3.9±1.2 and 4.1±1.3mg/dL, respectively; p<0.05). The uric acid levels were significantly higher in men presenting abdominal obesity, and among women with abdominal obesity, lower HDL-c levels and higher blood pressure (p<0.05). Conclusion: Uric acid concentrations were positively related to the occurrence of metabolic syndrome and its components, and there were differences between genders. Our results indicate serum uric acid as a potential biomarker for patients with cardiometabolic risk.
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    Relationship of oxidized low density lipoprotein with lipid profile and oxidative stress markers in healthy young adults : a translational study.
    (2011) Barbosa, Kiriaque Barra Ferreira; Volp, Ana Carolina Pinheiro; Hermsdorff, Helen Hermana Miranda; Blasco, Iñigo Navarro; Zulet, Maria Angeles; Martínez, José Alfredo; Bressan, Josefina
    Background: Despite oxidized low density lipoprotein (ox-LDL) plays important roles in the pro-inflammatory and atherosclerotic processes, the relationships with metabolic and oxidative stress biomarkers have been only scarcely investigated in young adult people. Thus, the aim of this study was to assess plasma ox-LDL concentrations and the potential association with oxidative stress markers as well as with anthropometric and metabolic features in healthy young adults. Methods: This study enrolled 160 healthy subjects (92 women/68 men; 23 ± 4 y; 22.0 ± 2.9 kg/m2). Anthropometry, body composition, blood pressure, lifestyle features, biochemical data, and oxidative stress markers were assessed with validated tools. Selenium, copper, and zinc nail concentrations were measured by atomic absorption spectrophotometry. Results: Total cholesterol (TC), LDL-c and uric acid concentrations, TC-to-HDL-c ratio, and glutathione peroxidase (GPx) activity were positive predictors of ox-LDL concentrations, while nail selenium level (NSL) was a negative predictor, independently of gender, age, smoking status, physical activity. Those individuals included in the highest tertile of GPx activity (≥611 nmol/[mL/min]) and of NSL (≥430 ng/g of nail) had higher and lower ox-LDL concentrations, respectively, independently of the same covariates plus truncal fat or body mass index, and total cholesterol or LDL-c concentrations. Conclusions: Ox-LDL concentrations were significantly associated with lipid biomarkers, GPx activity, uric acid concentration, and NSL, independently of different assayed covariates, in young healthy adults. These findings jointly suggest the early and complex relationship between lipid profile and redox status balance.
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    Ultra-processed food consumption and dietary, lifestyle and social determinants : a path analysis in Brazilian graduates - CUME project.
    (2022) Mattar, Jéssica Bevenuto; Domingos, Ana Luiza Gomes; Hermsdorff, Helen Hermana Miranda; Juvanhol, Leidjaira Lopes; Oliveira, Fernando Luiz Pereira de; Pimenta, Adriano Marçal; Bressan, Josefina
    Objective: To explore the relationship between ultra-processed foods (UPF) con- sumption and dietary, lifestyle and social determinants using pathway analysis in the baseline of the Cohort of Universities of Minas Gerais (CUME project). Design: Cross-sectional study, in which path analysis was used to estimate direct and indirect effects of dietary practices, sleep, time on the computer and profes- sional status on UPF consumption. Setting: Data were collected in 2016, through an online questionnaire composed of sociodemographic, anthropometric, lifestyle and dietary practices questions, and a FFQ. Participants: Baseline participants from the CUME Project (n 2826), adults who graduated from Universidade Federal de Viçosa or Universidade Federal de Minas Gerais, Brazil. Results: Being employed (P = 0·024), the time spent on the computer (P = 0·031) and the frequency of fried food intake (P < 0·001) were positively and directly associated with UPF consumption, whereas the sleep duration (P = 0·007) and the number of meals per d (P < 0·001) were negatively and directly associated with UPF consumption. Indirect effects were observed between being employed, medi- ated by the sleep duration (P = 0·032) and fried food intake (P = 0·005), whereas being a student is mediated by the time on the computer (P = 0·048). Conclusion: The time spent on the computer, sleep duration and fried food con- sumption showed direct effects on UPF consumption. They also acted as mediators on the relationship between professional status and UPF consumption. Besides, the number of meals eaten each day also was directly associated with UPF consumption.
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    Validation of metabolic syndrome and its self reported components in the CUME study.
    (2017) Miranda, Aline Elizabeth da Silva; Ferreira, Adaliene Versiani Matos; Oliveira, Fernando Luiz Pereira de; Hermsdorff, Helen Hermana Miranda; Bressan, Josefina; Pimenta, Adriano Marçal
    The aim of this study was to analyze the validity of self-reported diagnoses of metabolic syndrome (MetS) and its components through participants of the Cohort of Universities of Minas Gerais (CUME). A subsample of 172 cohort participants (33 males and 139 females, age 38 ± 11 years) was randomly selected for this study. The presence of MetS was defined according to the criteria of the International Diabetes Federation (IDF). Data on weight, height, blood pressure, and serum concentration of glucose, triglycerides and HDL-c were self reported in an online cohort questionnaire, and the same variables were measured using a standardized protocol in laboratories of higher education institutions involved in the project. Self-reported and measured data were compared by means of intraclass correlation coefficient (ICC), Kappa coefficient (k) and differences between self-reported and measured data, according to the Bland and Altman method. The prevalence of MetS was 4.7% and 5.2% according to self-reported and measured data, respectively. The Kappa coefficient between diagnoses of self-reported and measured MetS was 0.814, indicating almost perfect agreement, a situation similar to that observed for obesity (k = 0.882). The other components of MetS had moderate agreement (k = 0.41 to 0.60). The ICC also indicated excellent agreement for weight, height, BMI and HDL-c, respectively, 0.989, 0.995, 0.983 and 0.761. Glucose presented low agreement (ICC: 0.366). The study concludes that the CUME project participants provided valid information for the self-reported diagnoses of MetS and its components.
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    Vitamin C and fibre consumption from fruits and vegetables improves oxidative stress markers in healthy young adults.
    (2011) Hermsdorff, Helen Hermana Miranda; Barbosa, Kiriaque Barra Ferreira; Volp, Ana Carolina Pinheiro; Puchau, Blanca; Bressan, Josefina; Zulet, Maria Angeles; Martínez, José Alfredo
    The aim of the present cross-sectional study was to assess the potential relationships between fruit and vegetable (FV) consumption and some oxidative stress markers in young adults, with particular emphasis on fibre and vitamin C intake. The study enrolled 246 healthy subjects (eighty-eight men and 158 women), with a mean age of 22 (SD 3) years and a mean BMI of 21·9 (SD 2·8) kg/m2. Dietary intake, anthropometry, blood pressure, lifestyle features and blood biochemical data were assessed with validated procedures. Those subjects in the highest tertile (T) of FV consumption ($705 g/d) had statistically lower oxidised LDL (ox-LDL) concentrations as well as higher plasma total antioxidant capacity (TAC) and glutathione peroxidase (GPx) activity (P for trend ,0·05), after adjusting for sex, age, energy intake, physical activity, smoking, BMI, vitamin supplement use and other confounding factors. Moreover, plasma ox-LDL concentrations showed a decreasing trend and TAC an increasing trend across tertiles of fibre (T3: $14 g/d) and vitamin C (T3: $150 mg/d) from FV intake, while GPx activity was positively associated with vitamin C intake (P for trend ,0·05). In conclusion, greater FV consumption was independently associated with reduced ox-LDL as well as increased TAC and GPx activity in healthy young adults, with dietary fibre and vitamin C from FV clearly being implicated in this beneficial relationship.