Browsing by Author "Luu-Duc, Cuong"

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    Synthesis and microbiological activity of some 2H-1,4-benzothiazin-3-one derivatives.
    (2000) Guarda, Vera Lúcia de Miranda; Perrissin, Monique; Thomasson, François; Ximenes, Eulália Camelo Pessoa de Azevedo; Galdino, Suely Lins; Pitta, Ivan da Rocha; Luu-Duc, Cuong
    The synthesis and physicochemical properties of 4-butyl-2H-benzo[1,4]thiazin-3-one derivatives are described. These new compounds were synthesised by alkylation in 4-N position and acylation and/or alkylation of 6-NH2 by phase transfer catalysis. Acid hydrolysis of 6-alkylacylamino group yielded 6-alkylamino-4-butyl-2H-benzo[1,4]thiazin-3-ones. The antimicrobial in vitro activity was determined on five compounds.
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    Synthesis of 4-octyl-2H-1,4-benzo-thiazin-3-ones.
    (2003) Guarda, Vera Lúcia de Miranda; Perrissin, Monique; Thomasson, François; Ximenes, Eulália Camelo Pessoa de Azevedo; Galdino, Suely Lins; Pitta, Ivan da Rocha; Luu-Duc, Cuong; Barbe, Jacques
    Synthesis, physical and analytical properties of 6-alkylacylamino-4-octyl-2H-1,4-benzo-thiazin-3-ones derivatives are described. These new compounds were prepared by acylation and/or alkylation of the amino group under phase transfer catalysis conditions. Acid hydrolysis of the alkylacylamino-2H-1,4-benzo-thiazin-3-ones afforded N-alkylamino-benzothiazin-3-ones. Some of these compounds were evaluated in vitro for possible bacteriostatic activity.