Synthesis and microbiological activity of some 2H-1,4-benzothiazin-3-one derivatives.

Guarda, Vera Lúcia de Miranda; Perrissin, Monique; Thomasson, François; Ximenes, Eulália Camelo Pessoa de Azevedo; Galdino, Suely Lins; Pitta, Ivan da Rocha; Luu-Duc, Cuong

Synthesis and microbiological activity of some 2H-1,4-benzothiazin-3-one derivatives.

Date

2000

Authors

Guarda, Vera Lúcia de Miranda

Perrissin, Monique

Thomasson, François

Ximenes, Eulália Camelo Pessoa de Azevedo

Galdino, Suely Lins

Pitta, Ivan da Rocha

Luu-Duc, Cuong

Abstract

The synthesis and physicochemical properties of 4-butyl-2H-benzo[1,4]thiazin-3-one derivatives are described. These new compounds were synthesised by alkylation in 4-N position and acylation and/or alkylation of 6-NH2 by phase transfer catalysis. Acid hydrolysis of 6-alkylacylamino group yielded 6-alkylamino-4-butyl-2H-benzo[1,4]thiazin-3-ones. The antimicrobial in vitro activity was determined on five compounds.

Keywords

Benzothiazines, Antimicrobial activity

Citation

GUARDA, V. L. de M. et al. Synthesis and microbiological activity of some 2H-1,4-benzothiazin-3-one derivatives. Heterocyclic Communications, v. 06, n.01, p. 35-40, 2000. Disponível em: <https://www.degruyter.com/view/j/hc.2000.6.1/hc.2000.6.1.49/hc.2000.6.1.49.xml>. Acesso em: 20 jan. 2017.