Antiproliferative effect of benzophenones and their infl uence on cathepsin activity.
No Thumbnail Available
Date
2010
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
The antiproliferative activity of two prenylated benzophenones isolated from Rheedia brasiliensis, the triprenylated
garciniaphenone and the tetraprenylated benzophenone 7-epiclusianone, was investigated against
human cancer cell lines. The antiproliferative activity on melanoma (UACC-62), breast (MCF-7), drug-resistant
breast (NCI-ADR), lung/non-small cells (NCI460), ovarian (OVCAR 03), prostate (PC03), kidney (786-0),
lung (NCI-460) and tongue (CRL-1624 and CRL-1623) cancer cells was determined using spectrophotometric
quantifi cation of the cellular protein content. The effect of these benzophenones on the activity of cathepsins
B and G was also investigated. Garciniaphenone displayed cytostatic activity in all cell lines, whereas 7-
epiclusianone showed a dose-dependent cytotoxic effect. The IC50 values for cell proliferation revealed that
7-epiclusianone is more active than garciniaphenone against most of the cell lines. Furthermore, the antiproliferative
effects demonstrated by garciniaphenone and 7-epiclusianone were related to their cathepsin inhibiting
properties. In conclusion, 7-epiclusianone is a promising naturally occurring agent which displays multiple
inhibitory effects which may be working in concert to inhibit cancer cell proliferation in vitro. The putative
pathway by which 7-epiclusianone affects cancer cell development may involve cathepsin inhibition.
Description
Keywords
Antiproliferative, Cathepsin, Rheedia brasiliensis, Garciniaphenone
Citation
MURATA, R. M. et al. Antiproliferative effect of benzophenones and their infl uence on cathepsin activity. Phytotherapy Research , v. 24, p. 379-383, 2010. Disponível em: <http://onlinelibrary.wiley.com/doi/10.1002/ptr.2954/abstract>. Acesso em: 20 mai. 2017.