Antiproliferative effect of benzophenones and their infl uence on cathepsin activity.

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dc.contributor.authorMurata, Ramiro Mendonça
dc.contributor.authorYatsuda, Regiane
dc.contributor.authorSantos, Marcelo Henrique dos
dc.contributor.authorKohn, Luciana K.
dc.contributor.authorMartins, Felipe Terra
dc.contributor.authorNagem, Tanus Jorge
dc.contributor.authorAlencar, Severino Matias de
dc.contributor.authorCarvalho, João Ernesto de
dc.contributor.authorRosalen, Pedro Luiz
dc.date.accessioned2017-06-08T13:11:49Z
dc.date.available2017-06-08T13:11:49Z
dc.date.issued2010
dc.description.abstractThe antiproliferative activity of two prenylated benzophenones isolated from Rheedia brasiliensis, the triprenylated garciniaphenone and the tetraprenylated benzophenone 7-epiclusianone, was investigated against human cancer cell lines. The antiproliferative activity on melanoma (UACC-62), breast (MCF-7), drug-resistant breast (NCI-ADR), lung/non-small cells (NCI460), ovarian (OVCAR 03), prostate (PC03), kidney (786-0), lung (NCI-460) and tongue (CRL-1624 and CRL-1623) cancer cells was determined using spectrophotometric quantifi cation of the cellular protein content. The effect of these benzophenones on the activity of cathepsins B and G was also investigated. Garciniaphenone displayed cytostatic activity in all cell lines, whereas 7- epiclusianone showed a dose-dependent cytotoxic effect. The IC50 values for cell proliferation revealed that 7-epiclusianone is more active than garciniaphenone against most of the cell lines. Furthermore, the antiproliferative effects demonstrated by garciniaphenone and 7-epiclusianone were related to their cathepsin inhibiting properties. In conclusion, 7-epiclusianone is a promising naturally occurring agent which displays multiple inhibitory effects which may be working in concert to inhibit cancer cell proliferation in vitro. The putative pathway by which 7-epiclusianone affects cancer cell development may involve cathepsin inhibition.pt_BR
dc.identifier.citationMURATA, R. M. et al. Antiproliferative effect of benzophenones and their infl uence on cathepsin activity. Phytotherapy Research , v. 24, p. 379-383, 2010. Disponível em: <http://onlinelibrary.wiley.com/doi/10.1002/ptr.2954/abstract>. Acesso em: 20 mai. 2017.pt_BR
dc.identifier.doihttps://doi.org/10.1002/ptr.2954
dc.identifier.issn1099-1573
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/7922
dc.identifier.uri2http://onlinelibrary.wiley.com/doi/10.1002/ptr.2954/abstractpt_BR
dc.language.isoen_USpt_BR
dc.rightsrestritopt_BR
dc.subjectAntiproliferativept_BR
dc.subjectCathepsinpt_BR
dc.subjectRheedia brasiliensispt_BR
dc.subjectGarciniaphenonept_BR
dc.titleAntiproliferative effect of benzophenones and their infl uence on cathepsin activity.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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