Ruthenium(II)/triphenylphosphine complexes : an effective way to improve the cytotoxicity of lapachol.
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Date
2017
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Abstract
This study reports on the synthesis of a new ruthenium(II) complex, cis-[Ru(PPh3)2(lap)2] (1) with two
molecules of the natural product known as lapachol [lap = (2-hydroxy-3-(3-methyl-2-buthenyl)-1,4-
naphthoquinone)] coordinated as bidentated by oxygen atoms and two monodentate PPh3 (triphenylphosphine)
in a cis configuration. This neutral complex was characterized by spectroscopic analysis,
single-crystal X-ray diffraction, elemental analysis, molar conductivity and cyclic voltammetry. In this
study, ruthenium complex trans-[Ru(lap)(PPh3)2(phen)]PF6 (2) was used for comparison purposes. The
interaction of ruthenium complexes (1) and (2) with CT-DNA was evaluated by UV–Vis and circular
dichroism and it was observed that the complexes interact weakly with the CT-DNA. The fluorescence
measurements suggest that complex (1) shows stronger interaction with HSA and BSA proteins compared
to complex (2). Cytotoxicity assays against A549 (lung cancer), MDA-MB-231 (breast cancer) and V79
(non-tumoral lung) revealed that complex (2) is more active (lower IC50 values) than complex (1) and
the cisplatin, used as a reference.
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Keywords
Ruthenium complexes, Lapachol, Albumin binding, Cytotoxicity
Citation
OLIVEIRA, K. M. de et al. Ruthenium(II)/triphenylphosphine complexes: an effective way to improve the cytotoxicity of lapachol. Polyhedron, v. 130, p. 108-114, jul. 2017. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0277538717302723>. Acesso em: 15 set. 2017.