Ruthenium(II)/triphenylphosphine complexes : an effective way to improve the cytotoxicity of lapachol.

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dc.contributor.authorOliveira, Katia Mara de
dc.contributor.authorCorrea, Rodrigo de Souza
dc.contributor.authorBarbosa, Marília Imaculada Frazão
dc.contributor.authorEllena, Javier Alcides
dc.contributor.authorCominetti, Márcia Regina
dc.contributor.authorBatista, Alzir Azevedo
dc.date.accessioned2018-03-14T13:16:04Z
dc.date.available2018-03-14T13:16:04Z
dc.date.issued2017
dc.description.abstractThis study reports on the synthesis of a new ruthenium(II) complex, cis-[Ru(PPh3)2(lap)2] (1) with two molecules of the natural product known as lapachol [lap = (2-hydroxy-3-(3-methyl-2-buthenyl)-1,4- naphthoquinone)] coordinated as bidentated by oxygen atoms and two monodentate PPh3 (triphenylphosphine) in a cis configuration. This neutral complex was characterized by spectroscopic analysis, single-crystal X-ray diffraction, elemental analysis, molar conductivity and cyclic voltammetry. In this study, ruthenium complex trans-[Ru(lap)(PPh3)2(phen)]PF6 (2) was used for comparison purposes. The interaction of ruthenium complexes (1) and (2) with CT-DNA was evaluated by UV–Vis and circular dichroism and it was observed that the complexes interact weakly with the CT-DNA. The fluorescence measurements suggest that complex (1) shows stronger interaction with HSA and BSA proteins compared to complex (2). Cytotoxicity assays against A549 (lung cancer), MDA-MB-231 (breast cancer) and V79 (non-tumoral lung) revealed that complex (2) is more active (lower IC50 values) than complex (1) and the cisplatin, used as a reference.pt_BR
dc.identifier.citationOLIVEIRA, K. M. de et al. Ruthenium(II)/triphenylphosphine complexes: an effective way to improve the cytotoxicity of lapachol. Polyhedron, v. 130, p. 108-114, jul. 2017. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0277538717302723>. Acesso em: 15 set. 2017.pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.poly.2017.04.005
dc.identifier.issn0277-5387
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/9631
dc.identifier.uri2http://www.sciencedirect.com/science/article/pii/S0277538717302723pt_BR
dc.language.isoen_USpt_BR
dc.rightsrestritopt_BR
dc.subjectRuthenium complexespt_BR
dc.subjectLapacholpt_BR
dc.subjectAlbumin bindingpt_BR
dc.subjectCytotoxicitypt_BR
dc.titleRuthenium(II)/triphenylphosphine complexes : an effective way to improve the cytotoxicity of lapachol.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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