LINE-1 and inflammatory gene methylation levels are early biomarkers of metabolic changes : association with adiposity.
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Date
2016
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Abstract
We analyzed whether global and inflammatory genes methylation can be early predictors of metabolic
changes and their associations with the diet, in a cross-sectional study (n¼40). Higher global methylation
was associated to adiposity, insulin resistance, and lower quality of the diet. Methylation of IL-6,
SERPINE1 and CRP genes was related to adiposity traits and macronutrients intake. SERPINE1 hypermethylation
was also related to some metabolic alterations. CRP methylation was a better predictor of insulin
resistance than CRP plasma concentrations. Global and inflammatory gene promoter
hypermethylation can be good early biomarkers of adiposity and metabolic changes and are associated
to the quality of the diet.
Description
Keywords
Global DNA methylation, Healthy eating index, Metabolic syndrome
Citation
CARRARO, J. C. C. et al. LINE-1 and inflammatory gene methylation levels are early biomarkers of metabolic changes: association with adiposity. Biomarkers, v. 21, n. 7, p. 1-8, 2016. Disponível em: <http://www.tandfonline.com/doi/abs/10.3109/1354750X.2016.1171904?journalCode=ibmk20>. Acesso em: 29 ago. 2017.