LINE-1 and inflammatory gene methylation levels are early biomarkers of metabolic changes : association with adiposity.

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dc.contributor.authorCarraro, Júlia Cristina Cardoso
dc.contributor.authorMansego, Maria Luisa
dc.contributor.authorMilagro, Fermín Ignacio
dc.contributor.authorChaves, Larissa Oliveira
dc.contributor.authorVidigal, Fernanda de Carvalho
dc.contributor.authorBressan, Josefina
dc.contributor.authorMartinez, Alfredo
dc.date.accessioned2017-10-25T16:52:18Z
dc.date.available2017-10-25T16:52:18Z
dc.date.issued2016
dc.description.abstractWe analyzed whether global and inflammatory genes methylation can be early predictors of metabolic changes and their associations with the diet, in a cross-sectional study (n¼40). Higher global methylation was associated to adiposity, insulin resistance, and lower quality of the diet. Methylation of IL-6, SERPINE1 and CRP genes was related to adiposity traits and macronutrients intake. SERPINE1 hypermethylation was also related to some metabolic alterations. CRP methylation was a better predictor of insulin resistance than CRP plasma concentrations. Global and inflammatory gene promoter hypermethylation can be good early biomarkers of adiposity and metabolic changes and are associated to the quality of the diet.pt_BR
dc.identifier.citationCARRARO, J. C. C. et al. LINE-1 and inflammatory gene methylation levels are early biomarkers of metabolic changes: association with adiposity. Biomarkers, v. 21, n. 7, p. 1-8, 2016. Disponível em: <http://www.tandfonline.com/doi/abs/10.3109/1354750X.2016.1171904?journalCode=ibmk20>. Acesso em: 29 ago. 2017.pt_BR
dc.identifier.doihttps://doi.org/10.3109/1354750X.2016.1171904
dc.identifier.issn1752-0371
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/9045
dc.identifier.uri2http://www.tandfonline.com/doi/abs/10.3109/1354750X.2016.1171904?journalCode=ibmk20&pt_BR
dc.language.isoen_USpt_BR
dc.rightsrestritopt_BR
dc.subjectGlobal DNA methylationpt_BR
dc.subjectHealthy eating indexpt_BR
dc.subjectMetabolic syndromept_BR
dc.titleLINE-1 and inflammatory gene methylation levels are early biomarkers of metabolic changes : association with adiposity.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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