The anti-oxidant properties of isothiocyanates : a review.

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dc.contributor.authorFigueiredo, Sônia Maria de
dc.contributor.authorVieira Filho, Sidney Augusto
dc.contributor.authorMachado, José Augusto Nogueira
dc.contributor.authorCaligiorne, Rachel Basques
dc.date.accessioned2017-10-11T13:13:59Z
dc.date.available2017-10-11T13:13:59Z
dc.date.issued2013
dc.description.abstractCruciferous vegetables, such as broccoli and watercress, have been studied extensively aiming to evaluate their chemopreventive properties. Some of them have already been established using animal models. The ITCs induce Phase II enzymes related to detoxification processes of chemical carcinogens to prevent the start of carcinogenesis. They also exhibit antitumor activity at post-initiation phase, suggesting their additional role(s) in cancer prevention. Sulforaphane is the most extensively studied isothiocyanate, focused in its anti-tumoral activity and it is mainly found in great amounts in broccoli and other cruciferous. In a dose dependent manner, ITCs inhibit the cell viability of human cervical cancer cells, human pancreatic cancer cells, human hepatocellular carcinoma cells, human ovarian cancer cells, and have antiinflammatory properties in the treatment of human T-cell leukemia cells. This protective effect may be due to improved antioxidant status. Although the health effects of diet in humans are generally considered promising, there are definite challenges and limitations of the current data in better understanding of the molecular mechanisms responsible for this effect, together with the possible interactions between different dietary constituents. The survey of relevant patents on the use of isothiocyanates such as sulforaphane for cancer and cardiovascular diseases treatments is also included in this review.pt_BR
dc.identifier.citationFIGUEIREDO, S. M. de et al. The anti-oxidant properties of isothiocyanates: a review. Recent Patents on Endocrine, Metabolic & Immune Drug Discovery, v. 7, p. 213-225, 2013. Disponível em: <http://www.eurekaselect.com/114913/article>. Acesso em: 20 jan. 2017.pt_BR
dc.identifier.doihttps://doi.org/10.2174/18722148113079990011
dc.identifier.issn2212-3334
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/8928
dc.identifier.uri2http://www.eurekaselect.com/114913/articlept_BR
dc.language.isoen_USpt_BR
dc.rightsrestritopt_BR
dc.subjectBrassicaceaept_BR
dc.subjectCancer chemopreventionpt_BR
dc.subjectSulforaphanept_BR
dc.subjectDietpt_BR
dc.titleThe anti-oxidant properties of isothiocyanates : a review.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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