Simvastatin assay and dissolution studies by feasible rp-hplc in tablets.

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dc.contributor.authorMarinho, Flávia Dias Marques
dc.contributor.authorSantos, Amanda Leão dos
dc.contributor.authorSoares, Cristina Duarte Vianna
dc.contributor.authorReis, Ilka Afonso
dc.contributor.authorZanon, José Carlos da Costa
dc.contributor.authorLima, Angélica Alves
dc.date.accessioned2014-09-29T23:55:43Z
dc.date.available2014-09-29T23:55:43Z
dc.date.issued2012
dc.description.abstractCommonly used HPLC acetonitrile solvent has been through a worldwide shortage with a cost increase in 2008 and 2009. In order to get around this situation, a method by RP-HPLC employing methanol and aqueous acid mobile phase was developed and validated to evaluate simvastatin. The quality control assay and dissolution studies of this lipid-lowering drug were performed in diluents methanol and 0.01 M phosphate buffer with 0.5% SDS, pH 7, respectively. Dissolution test aliquots did not go through sample treatment, as described in USP SIM tablets monograph by ultraviolet spectrophotometry. The proposed method is fast, simple, feasible and robust.pt_BR
dc.identifier.citationMARINHO, F. D. M. et al. Simvastatin assay and dissolution studies by feasible rp-hplc in tablets. Química Nova, v. 35, p. 1233-1238, 2012. Disponível em: <http://www.scielo.br/scielo.php?pid=S0100-40422012000600031&script=sci_arttext>. Acesso em: 20 ago. 2014.pt_BR
dc.identifier.doihttp://dx.doi.org/10.1590/S0100-40422012000600031
dc.identifier.issn1678-7064
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/3639
dc.language.isoen_USpt_BR
dc.rights.licenseA Sociedade Brasileira de Química dá permissão à UFOP para reproduzir no RI/UFOP, uma cópia em formato eletrônico dos artigos completos, sem nenhuma edição e/ou modificação, publicados na revista Química Nova, que tenham como autores seus alunos e/ou professores. 17 set. 2013.pt_BR
dc.subjectSimvastatin tabletspt_BR
dc.subjectDissolution studiespt_BR
dc.titleSimvastatin assay and dissolution studies by feasible rp-hplc in tablets.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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