Trypanosoma cruzi : genetic diversity influences the profile of immunoglobulins during experimental infection.

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dc.contributor.authorSantos, Daniela Maria dos
dc.contributor.authorSilva, André Talvani Pedrosa da
dc.contributor.authorGuedes, Paulo Marcos da Matta
dc.contributor.authorCoelho, George Luiz Lins Machado
dc.contributor.authorLana, Marta de
dc.contributor.authorBahia, Maria Terezinha
dc.date.accessioned2012-07-09T17:47:06Z
dc.date.available2012-07-09T17:47:06Z
dc.date.issued2009
dc.description.abstractThe clonal evolution model postulated for Trypanosoma cruzi predicts a correlation between the phylogenetic divergence of T. cruzi clonal genotypes and their biological properties. In the present study, the linkage between phylogenetic divergence of the parasite and IgG, IgG1, IgG2a and IgG2b response has been evaluated during the acute and chronic phases of the experimental infection. Eight laboratory-cloned stocks representative of this phylogenetic diversity and including the lineages T. cruzi I (genotypes 19 and 20), T. cruzi II (genotype 32) and T. cruzi (genotype 39) have been studied. The results showed that the pattern of humoral immune response was correlated with T. cruzi genotype, and that stocks included in genotype 20 were responsible for the high IgG response in the acute and chronic phases. Moreover, T. cruzi I lineage was more efficient in over-expressing all subclasses of specific anti-parasite IgG than either T. cruzi II or T. cruzi lineages. Curiously, the alteration in the pattern of antibodies induced by Benznidazole treatment was related to the phase of the infection but not to the genotype of the parasite. The data suggest that genotypes of T. cruzi are able to drive levels/subclasses of specific IgG, hence giving rise to further concerns about the sensitivity of serological assays in the diagnosis of human Chagas disease.pt_BR
dc.identifier.citationSANTOS, D. M. dos et al. Trypanosoma cruzi : genetic diversity influences the profile of immunoglobulins during experimental infection. Experimental Parasitology, v. 121, n. 1, p. 8-14, jan. 2009. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0014489408002324>. Acesso em: 09 jul. 2012.pt_BR
dc.identifier.issn00144894
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/1015
dc.language.isoen_USpt_BR
dc.rights.licenseO periódico Experimental Parasitology concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3332590289434.
dc.subjectBenznidazolept_BR
dc.subjectTrypanosoma cruzipt_BR
dc.subjectGenetic diversitypt_BR
dc.subjectGenotypespt_BR
dc.subjectImmunoglobulin Gpt_BR
dc.titleTrypanosoma cruzi : genetic diversity influences the profile of immunoglobulins during experimental infection.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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