In vivo antimalarial efficacy of acetogenins, alkaloids and flavonoids enriched fractions from Annona crassiflora Mart.
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Date
2014
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Abstract
Annona crassiflora and Annonaceae plants are known to be used to treat malaria by
traditional healers. In this work, the antimalarial efficacy of different fractions of
A. crassiflora, particularly acetogenin, alkaloids and flavonoid-rich fractions, was
determined in vivo using Plasmodium berghei-infected mice model and toxicity was
accessed by brine shrimp assay. The A. crassiflora fractions were administered at doses
of 12.5 mg/kg/day in a 4-day test protocol. The results showed that some fractions from
woods were rich in acetogenins, alkaloids and terpenes, and other fractions from leaves
were rich in alkaloids and flavonoids. The parasitaemia was significantly ( p , 0.05,
p , 0.001) reduced (57–75%) with flavonoid and alkaloid-rich leaf fractions, which
also increased mean survival time of mice after treatment. Our results confirm the usage
of this plant in folk medicine as an antimalarial remedy.
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Keywords
Flavonoids, Aporphine alkaloids
Citation
PIMENTA, L. P. S. et al. In vivo antimalarial efficacy of acetogenins, alkaloids and flavonoids enriched fractions from Annona crassiflora Mart. Natural Product Research, v. online, p. 1-6, 2014. Disponível em: <http://www.tandfonline.com/doi/full/10.1080/14786419.2014.900496>. Acesso em: 20 jan. 2017.