Iron overload potentiates diet-induced hypercholesterolemia and reduces liver PPAR-α expression in hamsters.
No Thumbnail Available
Date
2012
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Iron stores and lipids are related to the
development of cardiovascular disease. Given that peroxisome
proliferator-activated receptor alpha (PPAR-α)
regulates important physiological processes that impact
lipid and glucose homeostasis, we decided to
investigate the effects of iron overload on serum
lipids and the liver expression of PPAR-α, 3-hydroxy-
3-methylglutaryl coenzyme A reductase, and cholesterol
7α-hydroxylase. Hamsters were divided into four
groups. The standard group (S) was fed the AIN-93M
diet, the SI group was fed the diet and iron injections,
the hypercholesterolemic group (H) was fed a
standard diet containing cholesterol, and the HI group
was fed a high-cholesterol diet and iron injections.
Serum cholesterol in the HI group was higher than
in the H group. Gene expression analysis of PPAR-α
showed that the HI group had a lower PPAR-α expression
than H. These data show that iron, when associated
with a high-fat diet, can cause increased serum
cholesterol levels, possibly due to a reduction in PPAR-
α expression.
Description
Keywords
Iron overload, Cholestero
Citation
BONOMO, L. de F. et al. Iron overload potentiates diet-induced hypercholesterolemia and reduces liver PPAR-α expression in hamsters. Journal of Biochemical and Molecular Toxicology, v. 26, p. 224-229, 2012. Disponível em: <http://onlinelibrary.wiley.com/doi/10.1002/jbt.21410/abstract>. Acesso em: 20 de jul. 2017.