Iron overload potentiates diet-induced hypercholesterolemia and reduces liver PPAR-α expression in hamsters.
| dc.contributor.author | Bonomo, Larissa de Freitas | |
| dc.contributor.author | Silva, Maísa | |
| dc.contributor.author | Oliveira, Riva de Paula | |
| dc.contributor.author | Silva, Marcelo Eustáquio | |
| dc.contributor.author | Pedrosa, Maria Lúcia | |
| dc.date.accessioned | 2017-08-14T13:16:43Z | |
| dc.date.available | 2017-08-14T13:16:43Z | |
| dc.date.issued | 2012 | |
| dc.description.abstract | Iron stores and lipids are related to the development of cardiovascular disease. Given that peroxisome proliferator-activated receptor alpha (PPAR-α) regulates important physiological processes that impact lipid and glucose homeostasis, we decided to investigate the effects of iron overload on serum lipids and the liver expression of PPAR-α, 3-hydroxy- 3-methylglutaryl coenzyme A reductase, and cholesterol 7α-hydroxylase. Hamsters were divided into four groups. The standard group (S) was fed the AIN-93M diet, the SI group was fed the diet and iron injections, the hypercholesterolemic group (H) was fed a standard diet containing cholesterol, and the HI group was fed a high-cholesterol diet and iron injections. Serum cholesterol in the HI group was higher than in the H group. Gene expression analysis of PPAR-α showed that the HI group had a lower PPAR-α expression than H. These data show that iron, when associated with a high-fat diet, can cause increased serum cholesterol levels, possibly due to a reduction in PPAR- α expression. | pt_BR |
| dc.identifier.citation | BONOMO, L. de F. et al. Iron overload potentiates diet-induced hypercholesterolemia and reduces liver PPAR-α expression in hamsters. Journal of Biochemical and Molecular Toxicology, v. 26, p. 224-229, 2012. Disponível em: <http://onlinelibrary.wiley.com/doi/10.1002/jbt.21410/abstract>. Acesso em: 20 de jul. 2017. | pt_BR |
| dc.identifier.doi | https://doi.org/10.1002/jbt.21410 | |
| dc.identifier.issn | 1099-0461 | |
| dc.identifier.uri | http://www.repositorio.ufop.br/handle/123456789/8528 | |
| dc.identifier.uri2 | http://onlinelibrary.wiley.com/doi/10.1002/jbt.21410/abstract | pt_BR |
| dc.language.iso | en_US | pt_BR |
| dc.rights | restrito | pt_BR |
| dc.subject | Iron overload | pt_BR |
| dc.subject | Cholestero | pt_BR |
| dc.title | Iron overload potentiates diet-induced hypercholesterolemia and reduces liver PPAR-α expression in hamsters. | pt_BR |
| dc.type | Artigo publicado em periodico | pt_BR |