Antibacterial activity of extract and fractions from branches of Protium spruceanum and cytotoxicity on fibroblasts.
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Date
2017
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Abstract
The crude ethanol extract (CEE) and fractions from branches of Protium
spruceanum were subjected to antibacterial and cytotoxicity assays.
Compounds of the most active fraction were identified by GC-MS
and LC-MS. CEE was active against 19 bacteria and the ethyl acetate
fraction (EAF) showed the lowest minimum bactericidal concentration
(MBC 0.3–80.0 mg/mL). Through time-kill assay was observed
that EAF induced rapid bactericidal effect against Staphylococcus
saprophyticus. The cytotoxicity tests against L929 fibroblasts showed
great potential of EAF on the treatment of infections caused by five
bacteria (MBC < IC50). The results provide in vitro scientific support to
the possible application of branches of P. spruceanum as antimicrobial
agent that may contribute for treatment of infections.
Description
Keywords
Protium spruceanum, Cytotoxicity, Antbacterial activity
Citation
AMPARO, T. R. et al. Antibacterial activity of extract and fractions from branches of Protium spruceanum and cytotoxicity on fibroblasts. Natural Product Research, v. 01, p. 1-5, 2017. Disponível em: <https://www.tandfonline.com/doi/abs/10.1080/14786419.2017.1354182?journalCode=gnpl20>. Acesso em: 05 abr. 2018.