Caspofungin effects on electrocardiogram of mice : an evaluation of cardiac safety.

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dc.contributor.authorPaula, Danielle Cristiane Correa de
dc.contributor.authorLeite, Elaine Amaral
dc.contributor.authorAraújo, Carolina Morais
dc.contributor.authorBranquinho, Renata Tupinambá
dc.contributor.authorGuimarães, Homero Nogueira
dc.contributor.authorGuimarães, Andrea Grabe
dc.date.accessioned2021-12-06T18:30:41Z
dc.date.available2021-12-06T18:30:41Z
dc.date.issued2021pt_BR
dc.description.abstractCaspofungin is an echinocandin, exhibiting efcacy against most Candida species invasive infection. Its cardiotoxicity was reported in isolated rat heart and ventricular myocytes, but in vivo and clinical studies are insufcient. Our objective was to evaluate caspofungin in vivo cardiac efects using an efcacious dose against Candida albicans. Female Swiss mice were infected with C. albicans, and treated with caspofungin, 5 or 10 mg/kg, intraperitoneal along 5 days. Survival rate and colony forming units (CFU) into vital organs were determined. For cardiac efects study, mice were treated with caspofungin 10 mg/ kg, and electrocardiogram (ECG) signal was obtained on C. albicans-infected mice, single dose-treated, and uninfected mice treated along 5 days, both groups to measure ECG intervals. Besides, ECG was also obtained by telemetry on uninfected mice to evaluate heart rate variability (HRV) parameters. The MIC for caspofungin on the wild-type C. albicans SC5314 strain was 0.3 μg/ml, indicating the susceptible. Survival rate increased signifcantly in infected mice treated with caspo fungin compared to mice treated with vehicle. None of the survived infected mice presented positive CFU after treatment with 10 mg/kg. C. albicans infection induced prolongation of QRS, QT, and QTc intervals; caspofungin did not alter this efect. Caspofungin induced increase of PR and an additional increase of QRS after 24 h of a single dose in infected mice. No signifcant alterations occurred in ECG intervals and HRV parameters of uninfected mice, after caspofungin treatment. Caspofungin showed in vivo cardiac relative safety maintaining its antifungal efcacy against C. albicans.pt_BR
dc.identifier.citationPAULA, D. C. C. de et al. Caspofungin effects on electrocardiogram of mice: an evaluation of cardiac safety. Cardiovascular Toxicology, v. 21, p. 93-105, 2021. Disponível em: <https://link.springer.com/article/10.1007%2Fs12012-020-09599-x>. Acesso em: 10 jun. 2021.pt_BR
dc.identifier.doihttps://doi.org/10.1007/s12012-020-09599-xpt_BR
dc.identifier.issn1559-0259
dc.identifier.urihttp://www.repositorio.ufop.br/jspui/handle/123456789/14088
dc.identifier.uri2https://link.springer.com/article/10.1007%2Fs12012-020-09599-xpt_BR
dc.language.isoen_USpt_BR
dc.rightsrestritopt_BR
dc.subjectCandida albicanspt_BR
dc.subjectQT intervalpt_BR
dc.subjectTelemetrypt_BR
dc.subjectHeart rate variabilitypt_BR
dc.titleCaspofungin effects on electrocardiogram of mice : an evaluation of cardiac safety.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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