Granulomatous hypersensitivity to Schistosoma mansoni egg antigens in human schistosomiasis. IV. A role for prostaglandin-induced inhibition of in vitro granuloma formation.
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Date
1994
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Abstract
The prostaglandins (PG) are known to regulate immune
cell function (s) and participate in the progression of both
acute and chronic inflammatory reactions. Using an in vitro
model of Schistosoma mansoni egg-induced hypersensitivity
granulomas, we have delineated the role of immune
complexes (IC) in the induction andrelease of PG and their
inhibitory effects on granuloma development. The hypersensitivity-
type granuloma reaction to soluble egg antigen
(SEA) was examined using a model of in vitro granuloma
,formation. Our results show that granuloma formation was
dramatically suppressed by the addition to the granuloma
cultures of IC, PGE,, PGE2, while PGF, alpha had no
significant effect. The inhibition of the PG function was
achieved by the introduction of anti-PG antibodies that
blocked suppression of granuloma,formation. It appears in
this model system that IC may inhibit the activity of
granuloma formation by stimulating the monocyte-macrophage
lineage to release inhibitory mediators. Our results
suggest that the prostaglandins E series may be important
in the generation and maintenance of suppression of the
granulomatous inflammatory response to S. mansoni egg
antigens .
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Keywords
Immune complexes, Mononuclear cells
Citation
GOES, A. M. et al. Granulomatous hypersensitivity to Schistosoma mansoni egg antigens in human schistosomiasis. IV. A role for prostaglandin-induced inhibition of in vitro granuloma formation. Parasite Immunology, v. 16, p. 11-18, 1994. Disponível em: <http://onlinelibrary.wiley.com/doi/10.1111/j.1365-3024.1994.tb00299.x/pdf>. Acesso em: 20 jan. 2017.