Differential expression of iron metabolism proteins in diabetic and diabetic iron-supplemented rat liver.

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dc.contributor.authorSilva, Maísa
dc.contributor.authorMagalhães, Cíntia Lopes de Brito
dc.contributor.authorOliveira, Riva de Paula
dc.contributor.authorSilva, Marcelo Eustáquio
dc.contributor.authorPedrosa, Maria Lúcia
dc.date.accessioned2017-08-11T12:59:54Z
dc.date.available2017-08-11T12:59:54Z
dc.date.issued2012
dc.description.abstractDiabetes mellitus is associated with altered iron homeostasis that can potentially effect reactive oxygen species generation and contribute to diabetes-related complications. We investigated, by quantitative polymerase chain reaction, whether the expression of liver hepcidin, ferritin, and TfR-1 is altered in diabetes. Rats in the control (C) group received a standard diet; control iron (CI) group received a standard diet supplemented with iron; diabetic (D) group received an injection of streptozotocin; and diabetic iron (DI) group received streptozotocin and the diet with iron.Animals of theDgroup showed higher levels of serum iron, increased concentration of carbonyl protein, and a decrease in antioxidant status. Group D rats showed increased hepatic expression of Trf-1 compared to the other groups. Iron supplementation reversed this increase. Hepcidin mRNA was 81% higher in DI than in C and CI rats. The results suggest that diabetes, with or without excess iron, can cause perturbations in iron status, hepcidin and Trf-1 expression.pt_BR
dc.identifier.citationSILVA, M. et al. Differential expression of iron metabolism proteins in diabetic and diabetic iron-supplemented rat liver. Journal of Biochemical and Molecular Toxicology, v. 26, p. 123-129, 2012. Disponível em: <http://onlinelibrary.wiley.com/doi/10.1002/jbt.20418/epdf>. Acesso em: 20 de jul. 2017.pt_BR
dc.identifier.doihttps://doi.org/10.1002/jbt.20418
dc.identifier.issn1099-0461
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/8527
dc.identifier.uri2http://onlinelibrary.wiley.com/doi/10.1002/jbt.20418/epdfpt_BR
dc.language.isoen_USpt_BR
dc.rightsrestritopt_BR
dc.subjectCarbonyl ironpt_BR
dc.subjectStreptozotocinpt_BR
dc.subjectHepcidinpt_BR
dc.subjectFerritinpt_BR
dc.titleDifferential expression of iron metabolism proteins in diabetic and diabetic iron-supplemented rat liver.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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