Hepatotoxicity of pentavalent antimonial drug : possible role of residual Sb(III) and protective effect of ascorbic acid.

Simple item page
dc.contributor.authorKato, Kelly Cristina
dc.contributor.authorTeixeira, Eliane Morais
dc.contributor.authorReis, Priscila Gomes dos
dc.contributor.authorBarcellos, Neila Marcia Silva
dc.contributor.authorSalaün, Pascal
dc.contributor.authorCampos, Paula Peixoto
dc.contributor.authorCorrêa Junior, José Dias
dc.contributor.authorRabello, Ana Lúcia Teles
dc.contributor.authorDemicheli, Cynthia Peres
dc.contributor.authorFrezard, Frederic Jean Georges
dc.date.accessioned2017-03-23T17:10:45Z
dc.date.available2017-03-23T17:10:45Z
dc.date.issued2013
dc.description.abstractPentavalent antimonial drugs such as meglumine antimoniate (Glucantime [Glu; Sanofi-Aventis, São Paulo, Brazil]) produce severe side effects, including cardiotoxicity and hepatotoxicity, during the treatment of leishmaniasis. We evaluated the role of residual Sb(III) in the hepatotoxicity of meglumine antimoniate, as well as the protective effect of the antioxidant ascorbic acid (AA) during antimonial chemotherapy in a murine model of visceral leishmaniasis. BALB/c mice infected with Leishmania infantum were treated intraperitoneally at 80 mg of Sb/kg/day with commercial meglumine antimoniate (Glu) or a synthetic meglumine antimoniate with lower Sb(III) level (MA), in association or not with AA (15 mg/kg/day), for a 20-day period. Control groups received saline or saline plus AA. Livers were evaluated for hepatocytes histological alterations, peroxidase activity, and apoptosis. Increased proportions of swollen and apoptotic hepatocytes were observed in animals treated with Glu compared to animals treated with saline or MA. The peroxidase activity was also enhanced in the liver of animals that received Glu. Cotreatment with AA reduced the extent of histological changes, the apoptotic index, and the peroxidase activity to levels corresponding to the control group. Moreover, the association with AA did not affect the hepatic uptake of Sb and the ability of Glu to reduce the liver and spleen parasite loads in infected mice. In conclusion, our data supports the use of pentavalent antimonials with low residue of Sb(III) and the association of pentavalent antimonials with AA, as effective strategies to reduce side effects in antimonial therapy.pt_BR
dc.identifier.citationKATO, K. C. et al. Hepatotoxicity of pentavalent antimonial drug: possible role of residual Sb(III) and protective effect of ascorbic acid. Antimicrobial Agents and Chemotherapy, v. 58, p. 481-488, 2013. Disponível em: <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910754/pdf/zac481.pdf>. Acesso em: 10 jan. 2017.pt_BR
dc.identifier.doihttp://dx.doi.org/10.1128/AAC.01499-13
dc.identifier.issn1098-6596
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/7444
dc.identifier.uri2https://aac.asm.org/content/58/1/481pt_BR
dc.language.isoen_USpt_BR
dc.rightsrestritopt_BR
dc.titleHepatotoxicity of pentavalent antimonial drug : possible role of residual Sb(III) and protective effect of ascorbic acid.pt_BR
dc.typeArtigo publicado em periodicopt_BR
Files
Collections
DEFAR - Artigos publicados em periódicos