Genetic composition of a Brazilian population : the footprint of the Gold Cycle.

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dc.contributor.authorQueiroz, Erica Maria de
dc.contributor.authorSantos, A. M.
dc.contributor.authorCastro, Ieso de Miranda
dc.contributor.authorCoelho, George Luiz Lins Machado
dc.contributor.authorMendes, Ana Paula Carlos Cândido
dc.contributor.authorLeite, Tailce Moura
dc.contributor.authorPereira, Rinaldo Wellerson
dc.contributor.authorFreitas, Renata Nascimento de
dc.date.accessioned2014-09-08T19:12:37Z
dc.date.available2014-09-08T19:12:37Z
dc.date.issued2013
dc.description.abstractAncestry-informative markers (AIMs) are powerful tools for inferring the genetic composition of admixed populations. In this study, we determined the genetic ancestry of the Ouro Preto (Brazil) population and evaluated the association between ancestry and self-reported skin color. The genetic ancestry of 189 children and adolescents was estimated by genotyping 15 AIMs. The estimate of population admixture was determined using the Bayesian Markov Chain Monte Carlo (MCMC) method implemented in two different programs (STRUCTURE and ADMIXMAP). Volunteers self-reported their skin colors. The European ancestry contribution ranged from 0.503 to 0.539, the African contribution ranged from 0.333 to 0.425, and the Amerindian component ranged from 0.04 to 0.164. The relative contributions of African (P < 0.016) and European (P < 0.011) ancestry differed significantly among skin color groups, except between black and dark-brown groups. The population of Ouro Preto has a higher contribution of African ancestry compared to the mean for the southeast region of Brazil. Therefore, extrapolating the African ancestry contribution for southeastern Brazil to the Ouro Preto population would underestimate the actual value for this city. We also showed that self-reported skin color could be appropriate for describing the genetic structure of this particular population.pt_BR
dc.identifier.citationQUEIROZ, E. M. de. el al. Genetic composition of a Brazilian population : the footprint of the Gold Cycle. Genetics and Molecular Research, v. 12, n. 4, p. 5124-5133, 2013. Disponível em: <https://geneticsmr.com/articles/2538>. Acesso em: 2 set. 2014.pt_BR
dc.identifier.doihttp://dx.doi.org/10.4238/2013.October.29.6
dc.identifier.issn1676-5680
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/3624
dc.language.isoen_USpt_BR
dc.rights.licenseA revista Genetics and Molecular Biology permite que o Repositório Institucional da Universidade Federal de Ouro Preto (UFOP) deposite uma cópia eletrônica dos artigos publicados por esse periódico  em que ao menos um dos autores faça parte da comunidade cientifica da UFOP. Fonte: Licença concedida mediante preenchimento de formulário no dia 19 nov. 2013.pt_BR
dc.subjectAncestry-informative markerspt_BR
dc.subjectGenetic ancestrypt_BR
dc.subjectSkin colorpt_BR
dc.subjectBrazilian populationpt_BR
dc.titleGenetic composition of a Brazilian population : the footprint of the Gold Cycle.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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