Development and validation of an analytical method for quantification of arsenic and antimony in liposomes using inductively coupled plasma-optical emission spectrometry.

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dc.contributor.authorReis, Priscila Gomes dos
dc.contributor.authorAbreu, Adriana Trópia de
dc.contributor.authorGuimarães, Andrea Grabe
dc.contributor.authorTeixeira, Mônica Cristina
dc.contributor.authorSouza, Jacqueline de
dc.contributor.authorBarcellos, Neila Marcia Silva
dc.date.accessioned2017-10-06T15:29:40Z
dc.date.available2017-10-06T15:29:40Z
dc.date.issued2013
dc.description.abstractArsenic and antimony compounds are used to treat endemic diseases, such as cancer, leishmaniasis, and schistosomiasis, in spite of their toxicity. Several studies seeking the development and characterization of nanocarrier systems such as liposomes are being carried out with the aim of developing new drug delivery systems and minimizing the toxicity of these drugs. However, the lack of reference methods to quantify these semimetals within a liposomal matrix hinders the QC of these formulations. Therefore, the validation of an analytical method for arsenic and antimony quantification in liposomal matrix by inductively coupled plasma-optical emission spectrometry is presented here. The linearity, specificity, LOD, LOQ, accuracy, and precision were determined according to the International Conference on Harmonization norms and the Brazilian Health Surveillance Agency (Resolution 899). The LOD values were 0.02 and 0.06 mg/L for antimony and arsenic, respectively. The LOQ for both was 3.0 mg/L, with an adequate accuracy within 98.26 and 101.32% for different levels of antimony and 99.98 and 100.36% for arsenic. Precision (CV) was lower than 5.0%. The developed and validated method was shown to be reproducible for quantification of arsenic and antimony in liposome pharmaceutical dosage forms.pt_BR
dc.identifier.citationREIS, P. G. dos et al. Development and validation of an analytical method for quantification of arsenic and antimony in liposomes using inductively coupled plasma-optical emission spectrometry. Journal of AOAC International, v. 96, p. 771-775, 2013. Disponível em: <http://aoac.publisher.ingentaconnect.com/contentone/aoac/jaoac/2013/00000096/00000004/art00018>. Acesso em: 06 out. 2017.pt_BR
dc.identifier.doihttps://doi.org/10.5740/jaoacint.10-263
dc.identifier.issn1944-7922
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/8890
dc.identifier.uri2http://aoac.publisher.ingentaconnect.com/contentone/aoac/jaoac/2013/00000096/00000004/art00018pt_BR
dc.language.isoen_USpt_BR
dc.rightsrestritopt_BR
dc.titleDevelopment and validation of an analytical method for quantification of arsenic and antimony in liposomes using inductively coupled plasma-optical emission spectrometry.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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