Amphotericin B-loaded Eudragit RL100 nanoparticles coated with hyaluronic acid for the treatment of vulvovaginal candidiasis.

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dc.contributor.authorMelo, Carolina Mirtes
dc.contributor.authorCardoso, Jéssica Ferreira
dc.contributor.authorPerasoli, Fernanda Barçante
dc.contributor.authorOliveira Neto, Ari Soares de
dc.contributor.authorPinto, Luccas Moreira
dc.contributor.authorMarques, Maria Betânia de Freitas
dc.contributor.authorMussel, Wagner da Nova
dc.contributor.authorMagalhães, Juliana Teixeira de
dc.contributor.authorMoura, Sandra Aparecida Lima de
dc.contributor.authorAraújo, Marcelo Gonzaga de Freitas
dc.contributor.authorSilva, Gisele Rodrigues da
dc.date.accessioned2020-05-18T17:13:07Z
dc.date.available2020-05-18T17:13:07Z
dc.date.issued2020
dc.description.abstractThe treatment of vulvovaginal candidiasis (VVC) is based on oral and vaginal formulations which show limited effectiveness. In this study, amphotericin B-loaded Eudragit RL100 nanoparticles coated with hyaluronic acid (AMP EUD nanoparticles/HA) were developed to overcome the drawbacks of the conventional formulations. AMP EUD nanoparticles/HA were synthesized by nanoprecipitation, formulated by statistical experimental design, and characterized. AMP release from EUD nanoparticles/HA and its antifungal activity in a murine model of VVC were evaluated. Nanoparticles showed 147.6 ± 16.7 nm of diameter, 0.301 ± 0.09 of polydispersity index, - 29.9 ± 3.76 mV of zeta potential, and 87.27 % of encapsulation efficiency. They released about 81 % of AMP in 96 h; and provided the elimination of 100 % of the vaginal fungal burden in 24 h. It was suggested that the AMP EUD nanoparticles/HA penetrated into the vaginal epithelium via CD44 receptors. These AMP EUD nanoparticles/HA represent a non-conventional vaginal formulation to improve the treatment of VVC.pt_BR
dc.identifier.citationMELO, C. M. et al. Amphotericin B-loaded Eudragit RL100 nanoparticles coated with hyaluronic acid for the treatment of vulvovaginal candidiasis. Carbohydrate Polymers, v. 230, p. 115608, fev. 2020. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0144861719312767>. Acesso em: 10 fev. 2020.pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.carbpol.2019.115608pt_BR
dc.identifier.issn0144-8617
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/12216
dc.identifier.uri2https://www.sciencedirect.com/science/article/pii/S0144861719312767pt_BR
dc.language.isoen_USpt_BR
dc.rightsrestritopt_BR
dc.titleAmphotericin B-loaded Eudragit RL100 nanoparticles coated with hyaluronic acid for the treatment of vulvovaginal candidiasis.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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