IL-10 plays a role in modulation of human granulomatous hypersensitivity against Schistosoma mansoni eggs induced by immune complexes.

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dc.contributor.authorRezende, Simone Aparecida
dc.contributor.authorTeixeira, David Nascimento Silva
dc.contributor.authorDrummond, Sandra Costa
dc.contributor.authorGoes, Alfredo Miranda de
dc.date.accessioned2017-04-07T14:28:14Z
dc.date.available2017-04-07T14:28:14Z
dc.date.issued1997
dc.description.abstractIt has been demonstrated that the chronic intestinal form of schistosomiasis is associated with the establishment and maintenance of a variety of immunoregulatory mechanisms that lead to a diminished granulomatous reaction to parasite eggs. Using an in vitro model of granuloma reaction we showed that immune complexes (IC) isolated from the sera of chronic intestinal schistosomiasis patients were able to reduce the granulomatous hypersensitivity (developed by peripheral blood mononuclear cells (PBMC) from schistosomiasis patients) to soluble egg antigen (SEA)-conjugated polyacrylamide beads (PB–SEA). This inhibitory activity, mediated by IC, was also observed in the proliferative response of PBMC stimulated with SEA and soluble worm antigen preparation (SWAP). Furthermore, we observed a decrease in TNF-α and an increase in IL-10 production by PBMC treated with IC in an in vitro granuloma reaction. This phenomenon was also seen in a cell proliferation assay when PBMC were treated with IC and stimulated with S. mansoni antigens. These results demonstrate that circulating IC may down-regulate PBMC reactivity to S. mansoni antigens by changing the cytokine pattern produced by these cells.pt_BR
dc.identifier.citationREZENDE, S. A. et al. IL-10 plays a role in modulation of human granulomatous hypersensitivity against Schistosoma mansoni eggs induced by immune complexes. Scandinavian Journal of Immunology, v. 46, p. 96-102, 1997. Disponível em: <http://onlinelibrary.wiley.com/doi/10.1046/j.1365-3083.1997.d01-92.x/epdf>. Acesso em: 20 jan. 2017.pt_BR
dc.identifier.doihttps://doi.org/10.1046/j.1365-3083.1997.d01-92.x
dc.identifier.issn 1365-3083
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/7575
dc.identifier.uri2http://onlinelibrary.wiley.com/doi/10.1046/j.1365-3083.1997.d01-92.x/epdfpt_BR
dc.language.isoen_USpt_BR
dc.rightsrestritopt_BR
dc.titleIL-10 plays a role in modulation of human granulomatous hypersensitivity against Schistosoma mansoni eggs induced by immune complexes.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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