Phytochemistry and antiplasmodial activity of Xylopia sericea leaves.

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dc.contributor.authorGontijo, Douglas da Costa
dc.contributor.authorNascimento, Maria Fernanda Alves do
dc.contributor.authorBrandão, Geraldo Célio
dc.contributor.authorOliveira, Alaide Braga de
dc.date.accessioned2020-05-18T16:43:11Z
dc.date.available2020-05-18T16:43:11Z
dc.date.issued2019
dc.description.abstractAiming to investigate the antiplasmodial activity and the phytochemical composition of Xylopia sericea leaves, the essential oil and dichloromethane extract were analyzed by gas and liquid chromatography, respectively, both of them coupled to mass spectrometry, and were evaluated against the chloroquine-resistant Plasmodium falciparum strain (W2) and for cytotoxicity to HepG2 cells. Low growth inhibition of P. falciparum as well as low cytotoxicity to HepG2 cells were observed for the essential oil. The leaves dichloromethane extract showed moderate growth inhibition of P. falciparum and low cytotoxicity to HepG2 cells. Bioguided chromatographic fractionation of this extract led to fractions with increased antiplasmodial activity from which liriodenine (IC50 6.1 ± 0.1 μg/mL, CC50 > 1000.0 μg/mL, SI > 164), an aporphine alkaloid, and an acetogenin-rich fraction containing mainly isomers of annomontacin and 4-deoxy-annomontacin (IC50 22.7 ± 1.9 µg/mL, CC50 336.1 ± 15.5 µg/mL, SI = 15) might be highlighted for their antiplasmodial activity.pt_BR
dc.identifier.citationGONTIJO, D. C. et al. Phytochemistry and antiplasmodial activity of Xylopia sericea leaves. Natural Product Research, fev. 2019. Disponível em: <https://www.tandfonline.com/doi/full/10.1080/14786419.2019.1577838>. Acesso em: 10 fev. 2020.pt_BR
dc.identifier.doihttps://doi.org/10.1080/14786419.2019.1577838pt_BR
dc.identifier.issn1478-6427
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/12214
dc.identifier.uri2https://www.tandfonline.com/doi/full/10.1080/14786419.2019.1577838pt_BR
dc.language.isoen_USpt_BR
dc.rightsrestritopt_BR
dc.subjectAnnonaceaept_BR
dc.subjectEssential oilpt_BR
dc.subjectDichloromethane extractpt_BR
dc.subjectAlkaloidspt_BR
dc.subjectAcetogeninspt_BR
dc.titlePhytochemistry and antiplasmodial activity of Xylopia sericea leaves.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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