Implants composed of digoxin and poly(ε-caprolactone) : development, characterization, anti-proliferative and anti-angiogenic activities.
| dc.contributor.author | Rodrigues, Felipe Fernandes | |
| dc.contributor.author | Braz, Wilson Rodrigues | |
| dc.contributor.author | Perasoli, Fernanda Barçante | |
| dc.contributor.author | Ferreira, Letícia Gonçalves Resende | |
| dc.contributor.author | Barbosa, Leandro Augusto de Oliveira | |
| dc.contributor.author | Silva, Gisele Rodrigues da | |
| dc.date.accessioned | 2019-04-17T14:03:59Z | |
| dc.date.available | 2019-04-17T14:03:59Z | |
| dc.date.issued | 2017 | |
| dc.description.abstract | Drug delivery systems could be applied to locally treat cervical cancer, thus preventing the drawbacks of conventional therapy. In this study, anti-proliferative and anti-angiogenic effects of digoxin incorporated into poly(ε-caprolactone) implants were evaluated, aiming at the local treatment of cervical cancer. Implants were characterized, and the in vitro release profile of digoxin was demonstrated. Anti-proliferative and anti-angiogenic activities of digoxin were investigated by using chorioallantoic membrane and human cervix carcinoma (HeLa) cells, respectively. The chemical structure of digoxin and the semi-crystalline nature of poly(ε-caprolactone) were preserved after designing implants. The hydrophobicity of drug and polymer as well as the semi-crystalline structure provided a controlled diffusion of digoxin from implants. Digoxin released from implantable devices exhibited anti-proliferative activity against HeLa cells. The anti-angiogenic effect was also shown. Finally, implants composed of digoxin and poly(ε-caprolactone) could be applied as a therapeutic alternative to treat the early stage of cervical cancer, once they were able to locally control the release of this anti-angiogenic and anti-proliferative drug, minimizing its systemic side effects and toxicity. | pt_BR |
| dc.identifier.citation | RODRIGUES, F. F. et al. Implants composed of digoxin and poly(ε-caprolactone) : development, characterization, anti-proliferative and anti-angiogenic activities. Pharmazie, v. 72, n. 7, p. 383–388, 2017. Disponível em: <https://www.ingentaconnect.com/contentone/govi/pharmaz/2017/00000072/00000007/art00002>. Acesso em: 25 fev. 2019. | pt_BR |
| dc.identifier.issn | 0031-7144 | |
| dc.identifier.uri | http://www.repositorio.ufop.br/handle/123456789/11059 | |
| dc.identifier.uri2 | https://www.ingentaconnect.com/contentone/govi/pharmaz/2017/00000072/00000007/art00002 | pt_BR |
| dc.language.iso | en_US | pt_BR |
| dc.rights | restrito | pt_BR |
| dc.title | Implants composed of digoxin and poly(ε-caprolactone) : development, characterization, anti-proliferative and anti-angiogenic activities. | pt_BR |
| dc.type | Artigo publicado em periodico | pt_BR |