The β-blocker carvedilol and the benznidazole modulate the cardiac immune response in the acute infection induced by Colombian strain of the Trypanosoma cruzi.
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Date
2018
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Abstract
BACKGROUND The infection led by Trypanosoma cruzi persists in mammalian tissues causing an inflammatory imbalance.
Carvedilol (Cv), a non-selective beta blocker drug indicated to treat heart failure and antihypertensive has shown to promote
antioxidant and immunomodulatory properties which might improve the inflammation induced by T. cruzi.
OBJECTIVES Evaluate the role of Cv on the inflammatory response of C57BL/6 mice acutely infected with the Colombian strain
of T. cruzi.
METHODS Animals were infected with the Colombian strain of T. cruzi and treated with Cv (25 mg/kg/day), benznidazole (Bz)
(100 mg/kg/day) or their combination. On the 28th day of infection and 23 days of treatment, the euthanasia occurred, and the
heart preserved for histopathological, oxidative stress (SOD, catalase, TBARs, carbonylated proteins) and plasma (CCL2, CCL5,
TNF, IL-10) analyses. Parasitaemia and survival were assessed along the infection.
FINDINGS Cv decreased TBARs, but increased the mortality rate, the parasitaemia and the levels of CCL2, CCL5, catalase and
the inflammatory infiltrate in the cardiac tissue. Bz led the reduction of the inflammatory infiltrate and circulating levels of
oxidative stress and inflammatory mediators in the infected mice.
MAIN CONCLUSIONS Our data suggest that Cv, in this experimental model using the Colombian strain of T. cruzi, caused
damage to the host.
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Keywords
Inflammation, Heart disease, Chemokines
Citation
HORTA, A. L. et al. The β-blocker carvedilol and the benznidazole modulate the cardiac immune response in the acute infection induced by Colombian strain of the Trypanosoma cruzi. Memórias do Instituto Oswaldo Cruz, v. 113, n. 11, p. 1-8, 2018. Disponível em: <http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0074-02762018001100301&lng=pt&nrm=iso&tlng=pt>. Acesso em: 22 fev. 2019.