The β-blocker carvedilol and the benznidazole modulate the cardiac immune response in the acute infection induced by Colombian strain of the Trypanosoma cruzi.

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dc.contributor.authorHorta, Aline Luciano
dc.contributor.authorFigueiredo, Vivian Paulino
dc.contributor.authorLeite, Ana Luísa Junqueira
dc.contributor.authorCosta, Guilherme de Paula
dc.contributor.authorMenezes, Ana Paula de Jesus
dc.contributor.authorRamos, Camila de Oliveira
dc.contributor.authorPedrosa, Tamiles Caroline Fernandes
dc.contributor.authorBezerra, Frank Silva
dc.contributor.authorVieira, Paula Melo de Abreu
dc.contributor.authorSilva, André Talvani Pedrosa da
dc.date.accessioned2019-04-08T18:02:55Z
dc.date.available2019-04-08T18:02:55Z
dc.date.issued2018
dc.description.abstractBACKGROUND The infection led by Trypanosoma cruzi persists in mammalian tissues causing an inflammatory imbalance. Carvedilol (Cv), a non-selective beta blocker drug indicated to treat heart failure and antihypertensive has shown to promote antioxidant and immunomodulatory properties which might improve the inflammation induced by T. cruzi. OBJECTIVES Evaluate the role of Cv on the inflammatory response of C57BL/6 mice acutely infected with the Colombian strain of T. cruzi. METHODS Animals were infected with the Colombian strain of T. cruzi and treated with Cv (25 mg/kg/day), benznidazole (Bz) (100 mg/kg/day) or their combination. On the 28th day of infection and 23 days of treatment, the euthanasia occurred, and the heart preserved for histopathological, oxidative stress (SOD, catalase, TBARs, carbonylated proteins) and plasma (CCL2, CCL5, TNF, IL-10) analyses. Parasitaemia and survival were assessed along the infection. FINDINGS Cv decreased TBARs, but increased the mortality rate, the parasitaemia and the levels of CCL2, CCL5, catalase and the inflammatory infiltrate in the cardiac tissue. Bz led the reduction of the inflammatory infiltrate and circulating levels of oxidative stress and inflammatory mediators in the infected mice. MAIN CONCLUSIONS Our data suggest that Cv, in this experimental model using the Colombian strain of T. cruzi, caused damage to the host.pt_BR
dc.identifier.citationHORTA, A. L. et al. The β-blocker carvedilol and the benznidazole modulate the cardiac immune response in the acute infection induced by Colombian strain of the Trypanosoma cruzi. Memórias do Instituto Oswaldo Cruz, v. 113, n. 11, p. 1-8, 2018. Disponível em: <http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0074-02762018001100301&lng=pt&nrm=iso&tlng=pt>. Acesso em: 22 fev. 2019.pt_BR
dc.identifier.issn00740276
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/10967
dc.language.isoen_USpt_BR
dc.rightsabertopt_BR
dc.rights.licenseTodo o conteúdo do periódico Memórias do Instituto Oswaldo Cruz, exceto onde identificado, está licenciado sob uma licença Creative Commons 4.0 que permite copiar, distribuir e transmitir o trabalho em qualquer suporte ou formato desde que sejam citados o autor e o licenciante. Fonte: Memórias do Instituto Oswaldo Cruz <http://www.scielo.br/scielo.php/script_sci_serial/pid_0074-0276/lng_pt/nrm_iso>. Acesso em: 03 jan. 2017.pt_BR
dc.subjectInflammationpt_BR
dc.subjectHeart diseasept_BR
dc.subjectChemokinespt_BR
dc.titleThe β-blocker carvedilol and the benznidazole modulate the cardiac immune response in the acute infection induced by Colombian strain of the Trypanosoma cruzi.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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