Lycopene pretreatment improves hepatotoxicity induced by acetaminophen in C57BL/6 mice.
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Date
2017
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Abstract
Acetaminophen (APAP) is an antipyretic and analgesic drug that, in high doses, leads to severe liver injury
and potentially death. Oxidative stress is an important event in APAP overdose. Researchers are looking
for natural antioxidants with the potential to mitigate the harmful effects of reactive oxygen species in
different models. Lycopene has been widely studied for its antioxidant properties. The aim of this study
was to evaluate the antioxidant potential of lycopene pretreatment in APAP-induced liver injury in
C57BL/6 mice. C57BL/6 male mice were divided into the following groups: control (C); sunflower oil
(CO); acetaminophen 500 mg/kg (APAP); acetaminophen 500 mg/kg + lycopene 10 mg/kg (APAP + L10),
and acetaminophen 500 mg/kg + lycopene 100 mg/kg (APAP + L100). Mice were pretreated with lycopene
for 14 consecutive days prior to APAP overdose. Analyses of blood serum and livers were performed.
Lycopene was able to improve redox imbalance, decrease thiobarbituric acid reactive species level, and
increase CAT and GSH levels. In addition, it decreased the IL-1b expression and the activity of MMP-2.
This study revealed that preventive lycopene consumption in C57BL/6 mice can attenuate the effects
of APAP-induced liver injury. Furthermore, by improving the redox state, and thus indicating its potential
antioxidant effect, lycopene was also shown to have an influence on inflammatory events.
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Keywords
Redox imbalance, Inflammation
Citation
BANDEIRA, A. C. B. et al. Lycopene pretreatment improves hepatotoxicity induced by acetaminophen in C57BL/6 mice. Bioorganic & Medicinal Chemistry, v. 25, p. 1057-1065, 2017. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0968089616310525>. Acesso em: 15 set. 2017.