Lycopene pretreatment improves hepatotoxicity induced by acetaminophen in C57BL/6 mice.

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dc.contributor.authorBandeira, Ana Carla Balthar
dc.contributor.authorSilva, Rafaella Cecília da
dc.contributor.authorRossoni Júnior, Joamyr Victor
dc.contributor.authorFigueiredo, Vivian Paulino
dc.contributor.authorSilva, André Talvani Pedrosa da
dc.contributor.authorCangussú, Silvia Dantas
dc.contributor.authorBezerra, Frank Silva
dc.contributor.authorCosta, Daniela Caldeira
dc.date.accessioned2017-11-17T13:27:43Z
dc.date.available2017-11-17T13:27:43Z
dc.date.issued2017
dc.description.abstractAcetaminophen (APAP) is an antipyretic and analgesic drug that, in high doses, leads to severe liver injury and potentially death. Oxidative stress is an important event in APAP overdose. Researchers are looking for natural antioxidants with the potential to mitigate the harmful effects of reactive oxygen species in different models. Lycopene has been widely studied for its antioxidant properties. The aim of this study was to evaluate the antioxidant potential of lycopene pretreatment in APAP-induced liver injury in C57BL/6 mice. C57BL/6 male mice were divided into the following groups: control (C); sunflower oil (CO); acetaminophen 500 mg/kg (APAP); acetaminophen 500 mg/kg + lycopene 10 mg/kg (APAP + L10), and acetaminophen 500 mg/kg + lycopene 100 mg/kg (APAP + L100). Mice were pretreated with lycopene for 14 consecutive days prior to APAP overdose. Analyses of blood serum and livers were performed. Lycopene was able to improve redox imbalance, decrease thiobarbituric acid reactive species level, and increase CAT and GSH levels. In addition, it decreased the IL-1b expression and the activity of MMP-2. This study revealed that preventive lycopene consumption in C57BL/6 mice can attenuate the effects of APAP-induced liver injury. Furthermore, by improving the redox state, and thus indicating its potential antioxidant effect, lycopene was also shown to have an influence on inflammatory events.pt_BR
dc.identifier.citationBANDEIRA, A. C. B. et al. Lycopene pretreatment improves hepatotoxicity induced by acetaminophen in C57BL/6 mice. Bioorganic & Medicinal Chemistry, v. 25, p. 1057-1065, 2017. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0968089616310525>. Acesso em: 15 set. 2017.pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.bmc.2016.12.018
dc.identifier.issn0968-0896
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/9158
dc.language.isoen_USpt_BR
dc.rightsabertopt_BR
dc.rights.licenseO periódico Bioorganic & Medicinal Chemistry concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 4210821115986.pt_BR
dc.subjectRedox imbalancept_BR
dc.subjectInflammationpt_BR
dc.titleLycopene pretreatment improves hepatotoxicity induced by acetaminophen in C57BL/6 mice.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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