Trypanosoma cruzi : induction of benznidazole resistance in vivo and its modulation by in vitro culturing and mice infection.

Simple item page
dc.contributor.authorSantos, Fabiane Matos dos
dc.contributor.authorCaldas, Sérgio
dc.contributor.authorCáu, Stêfany Bruno de Assis
dc.contributor.authorCrepalde, Geovam Pereira
dc.contributor.authorLana, Marta de
dc.contributor.authorCoelho, George Luiz Lins Machado
dc.contributor.authorVeloso, Vanja Maria
dc.contributor.authorBahia, Maria Terezinha
dc.date.accessioned2014-11-10T17:01:47Z
dc.date.available2014-11-10T17:01:47Z
dc.date.issued2008
dc.description.abstractThrough a continuous in vivo drug pressure protocol, using mice as experimental model, we induced benznidazole resistance in Trypanosoma cruzi stocks. Full resistance was obtained for four out of five T. cruzi stocks analyzed. However, the number of benznidazole doses (40–180), as well as the time (4–18 months) necessary to induce resistance varied among the different T. cruzi stocks. The resistance phenotype remained stable after T. cruzi stocks has been maintained by 12 passages in mice (six months) and in acellular culture for the same time. However, the maintenance of resistant parasite for 12 months in acellular culture induces a reduction in its level of benznidazole resistance, while no alteration was detected in parasite maintained for the same time in mice. The data showed the stability of the resistance acquired by drug pressure, but suggest the possibility of reversible changes in the resistance levels after maintenance for long time in acellular culture.pt_BR
dc.identifier.citationSANTOS, F. M. et al. Trypanosoma cruzi : induction of benznidazole resistance in vivo and its modulation by in vitro culturing and mice infection. Experimental Parasitology, v. 120, p. 385-390, 2008. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0014489408002269>. Acesso em: 20 ago. 2014.pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.exppara.2008.09.007
dc.identifier.issn0014-4894
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/3747
dc.language.isoen_USpt_BR
dc.rights.licenseO periódico Experimental Parasitology concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3460321119735.pt_BR
dc.subjectTrypanosoma cruzipt_BR
dc.subjectDrug resistancept_BR
dc.subjectChemotherapypt_BR
dc.subjectTreatment cyclept_BR
dc.subjectBenznidazolept_BR
dc.titleTrypanosoma cruzi : induction of benznidazole resistance in vivo and its modulation by in vitro culturing and mice infection.pt_BR
dc.typeArtigo publicado em periodicopt_BR
Files
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
ARTIGO_TrypanossomaCruziInduction.pdf
Size:
250.7 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
DEFAR - Artigos publicados em periódicos