Influence of the long-term Trypanosoma cruzi infection in vertebrate host on the genetic and biological diversity of the parasite.

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dc.contributor.authorVeloso, Vanja Maria
dc.contributor.authorRomanha, Alvaro José
dc.contributor.authorLana, Marta de
dc.contributor.authorMurta, Silvane Maria Fonseca
dc.contributor.authorCarneiro, Claudia Martins
dc.contributor.authorAlves, Cíntia Fontes
dc.contributor.authorBorges, Erika Carime
dc.contributor.authorTafuri, Washington Luiz
dc.contributor.authorCoelho, George Luiz Lins Machado
dc.contributor.authorChiari, Egler
dc.contributor.authorBahia, Maria Terezinha
dc.date.accessioned2017-03-07T16:23:39Z
dc.date.available2017-03-07T16:23:39Z
dc.date.issued2005
dc.description.abstractThe influence of the long-term Trypanosoma cruzi infection in vertebrate host on the biological and genetic properties of the parasite was evaluated. Four T. cruzi isolates obtained from different chronic chagasic dogs infected with Berenice-78 T. cruzi strain during 2 and 7 years were comparatively analyzed. The long-term T. cruzi infection has led to alterations in parasitemia, virulence and pathogenicity of Be-78 strain for mice. These biological parameters varied from low to high in realation to the parental strain. Randomly amplified polymorphic DNA and isoenzyme profiles detected two distinct genetic groups of parasites. The first group included the parental strain and two T. cruzi isolates, and the second group the two other isolates. Interestingly, the isolates of the second group showed a reversibility of the genetic profile to the parental strain after 25 passages in mice. No correlation between the genetic groups and biological properties of the isolates was observed. Our findings confirmed the population heterogeneity of the Be-78 strain, and showed how differently it responds to the long-term infection in the same vertebrate hosts.pt_BR
dc.identifier.citationVELOSO, V. M. et al. Influence of the long-term Trypanosoma cruzi infection in vertebrate host on the genetic and biological diversity of the parasite. Parasitology Research, v. 96, p.382-389, 2005. Disponível em: <http://link.springer.com/article/10.1007/s00436-005-1373-z>. Acesso em: 10 jan. 2017.pt_BR
dc.identifier.doihttps://doi.org/10.1007/s00436-005-1373-z
dc.identifier.issn1432-1955
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/7325
dc.identifier.uri2http://link.springer.com/article/10.1007/s00436-005-1373-zpt_BR
dc.language.isoen_USpt_BR
dc.rightsrestritopt_BR
dc.titleInfluence of the long-term Trypanosoma cruzi infection in vertebrate host on the genetic and biological diversity of the parasite.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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