Ageing down-modulates liver inflammatory immune responses to schistosome infection in mice.

Faria, Elaine Speziali de; Aranha, Claudio Henrique Magalhães; Carvalho, Andréa Teixeira de; Santiago, Andrezza Fernanda; Oliveira, Rafael Pires de; Rezende, Michelle Carvalho de; Carneiro, Claudia Martins; Corrêa, Deborah Aparecida Negrão; Coelho, Paulo Marcos Zech; Faria, Ana Maria Caetano de

Ageing down-modulates liver inflammatory immune responses to schistosome infection in mice.

Date

2010

Authors

Faria, Elaine Speziali de

Aranha, Claudio Henrique Magalhães

Carvalho, Andréa Teixeira de

Santiago, Andrezza Fernanda

Oliveira, Rafael Pires de

Rezende, Michelle Carvalho de

Carneiro, Claudia Martins

Corrêa, Deborah Aparecida Negrão

Coelho, Paulo Marcos Zech

Faria, Ana Maria Caetano de

Abstract

Ageing is associated with several alterations in the immune system. Our aim in this study was to compare the development of immunity to Schistosoma mansoni infection in young versus aged C57Bl ⁄ 6 mice using the liver as the main organ to evaluate pathological alterations and immune responses. In the acute phase, young mice had large liver granulomas with fibrosis and inflammatory cells. Chronic phase in young animals was associated with immunomodulation of granulomas that became reduced in size and cellular infiltrate. On the other hand, aged animals presented granulomas of smaller sizes already in the acute phase. Chronic infection in these mice was followed by no alteration in any of the inflammatory parameters in the liver. In concert with this finding, there was an increase in activated CD4+ T, CD19+ B and NK liver cells in young mice after infection whereas old mice had already higher frequencies of activated B, NK and CD4+ T liver cells and infection does not change these frequencies. After infection, liver production of inflammatory and regulatory cytokines such as IFN-c, IL-4 and IL-10 increased in young but not in old mice that had high levels of IL-4 and IL-10 regardless of their infection status. Our data suggest that the unspecific activation status of the immune system in aged mice impairs inflammatory as well as regulatory immune responses to S. mansoni infection in the liver, where major pathological alterations and immunity are at stage. This poor immune reactivity may have a beneficial impact on disease development.

Citation

FARIA, E. S. et al. Ageing down-modulates liver inflammatory immune responses to schistosome infection in mice. Scandinavian Journal of Immunology, v. 71, p.240-248, 2010. Disponível em: <http://onlinelibrary.wiley.com/doi/10.1111/j.1365-3083.2010.02370.x/abstract>. Acesso em: 10 jan. 2017.