2,2’,4-Trihydroxybenzophenone : crystal structure, and anti-inflammatory and antioxidant activities.

Doriguetto, Antônio Carlos; Martins, Felipe Terra; Ellena, Javier Alcides; Salloum, Rogério; Santos, Marcelo Henrique dos; Moreira, Maria Eliza de Castro; Silva, Jose Mauricio Schneedorf Ferreira da; Nagem, Tanus Jorge

2,2’,4-Trihydroxybenzophenone : crystal structure, and anti-inflammatory and antioxidant activities.

Date

2007

Authors

Doriguetto, Antônio Carlos

Martins, Felipe Terra

Ellena, Javier Alcides

Salloum, Rogério

Santos, Marcelo Henrique dos

Moreira, Maria Eliza de Castro

Silva, Jose Mauricio Schneedorf Ferreira da

Nagem, Tanus Jorge

Abstract

The crystal structure of C 2,2’,4-trihydroxybenzophenoneD (¼(2,4-dihydroxyphenyl)(2-hydroxyphenyl) methanone; 1) was determined, and its molecular structure, along with intra- and intermolecular Hbonds, was analyzed. The anti-inflammatory potential of 1, evaluated by means of the rat-paw-edema assay, with carrageenan as inflammation stimulus, was found to be similar high as that of indomethacin. In contrast, benzophenone proper (2) was hardly active in this assay. Our results indicate that these antiinflammatory effects are related to the action of kinins and prostaglandins. The radical-scavenging properties of 1 towards DPPH were found to be similar as those of typical phenolics, but somewhat lower than that of ascorbic acid. The structure–activity relationship (SAR) of 1 is discussed.

Citation

DORIGUETTO, A. C. et al. 2,2’,4-Trihydroxybenzophenone: crystal structure, and anti-inflammatory and antioxidant activities. Chemistry & Biodiversity, v. 4, p. 488-499, 2007. Disponível em: <http://onlinelibrary.wiley.com/doi/10.1002/cbdv.200790041/abstract>. Acesso em: 20 mai. 2017.