2,2’,4-Trihydroxybenzophenone : crystal structure, and anti-inflammatory and antioxidant activities.

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dc.contributor.authorDoriguetto, Antônio Carlos
dc.contributor.authorMartins, Felipe Terra
dc.contributor.authorEllena, Javier Alcides
dc.contributor.authorSalloum, Rogério
dc.contributor.authorSantos, Marcelo Henrique dos
dc.contributor.authorMoreira, Maria Eliza de Castro
dc.contributor.authorSilva, Jose Mauricio Schneedorf Ferreira da
dc.contributor.authorNagem, Tanus Jorge
dc.date.accessioned2017-06-19T14:34:17Z
dc.date.available2017-06-19T14:34:17Z
dc.date.issued2007
dc.description.abstractThe crystal structure of C 2,2’,4-trihydroxybenzophenoneD (¼(2,4-dihydroxyphenyl)(2-hydroxyphenyl) methanone; 1) was determined, and its molecular structure, along with intra- and intermolecular Hbonds, was analyzed. The anti-inflammatory potential of 1, evaluated by means of the rat-paw-edema assay, with carrageenan as inflammation stimulus, was found to be similar high as that of indomethacin. In contrast, benzophenone proper (2) was hardly active in this assay. Our results indicate that these antiinflammatory effects are related to the action of kinins and prostaglandins. The radical-scavenging properties of 1 towards DPPH were found to be similar as those of typical phenolics, but somewhat lower than that of ascorbic acid. The structure–activity relationship (SAR) of 1 is discussed.pt_BR
dc.identifier.citationDORIGUETTO, A. C. et al. 2,2’,4-Trihydroxybenzophenone: crystal structure, and anti-inflammatory and antioxidant activities. Chemistry & Biodiversity, v. 4, p. 488-499, 2007. Disponível em: <http://onlinelibrary.wiley.com/doi/10.1002/cbdv.200790041/abstract>. Acesso em: 20 mai. 2017.pt_BR
dc.identifier.doihttps://doi.org/10.1002/cbdv.200790041
dc.identifier.issn1612-1880
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/7982
dc.identifier.uri2http://onlinelibrary.wiley.com/doi/10.1002/cbdv.200790041/abstractpt_BR
dc.language.isoen_USpt_BR
dc.rightsrestritopt_BR
dc.title2,2’,4-Trihydroxybenzophenone : crystal structure, and anti-inflammatory and antioxidant activities.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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